トップ > 製品検索結果一覧 > Code No. SY-001 Anti-Fas (CD95) (Human) mAb

Code No. SY-001

Anti-Fas (CD95) (Human) mAb

価格(税別)

¥64,000

在庫

10以上

(2020/10/31 17:00時点)

包装

50 µg/100 µL

クローナリティー Monoclonal クローン CH-11
アイソタイプ
(免疫動物)
Mouse IgM
使用法
WB
20 µg/mL  
FCM
20 µg/mL (final conc.)  
Function
Induction of apoptosis  
免疫原(抗原) human diploid fibroblast FS-7 cell line
交差性
[Gene ID]

Human[355], Mouse(-)

性状 500 µg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C 標識 Unlabeled メーカー MBL
別称 FAS1, APT1, TNFRSF6, APO-1, FASTM, ALPS1A
背景 It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.
関連製品 MD-11-3 Anti-Fas (CD95) (Human) mAb
MD-10-3 Anti-Fas (CD95) (Human) mAb
MD-10-A48 Anti-Fas (CD95) (Human) mAb-Alexa Fluor® 488
MD-10-4 Anti-Fas (CD95) (Human) mAb-FITC
MD-10-5 Anti-Fas (CD95) (Human) mAb-PE
M079-3 Mouse IgM (isotype control)
8442 MEBSTAIN Apoptosis TUNEL Kit III
M059-3 Anti-Caspase-10 (Human) mAb
D161-3 Anti-MFG-E8 (Mouse) mAb
備考 100 ng/mLの濃度で37℃2時間反応後アポトーシスを誘導し、15時間後にはほぼ全ての細胞が細胞死します。
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。

Western Blotting

  1. Masuda A et al. Efficient Recruitment of c-FLIPL to the Death-Inducing Signaling Complex Leads to Fas Resistance in Natural Killer-Cell Lymphoma. Cancer Sci. 111, 807-816 (2020) (PMID:31908105)

Neutralization

  1. Takaki S, Eto K. Cytoplasmic localization of programmed cell death 4 contributes to its anti-apoptotic function. Mol Cell Biochem. 448, 155-164 (2018)(PMID:29442268)

Function

  1. Zanin-Zhorov A et al. Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells. J Immunol. 171, 5882-9 (2003)(PMID:14634098)
  2. López-Huertas MR et al. The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production. J Biol Chem. 288, 7626-44 (2013)(PMID:23364796)
  3. Murthy A et al. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506, 456-62 (2014)(PMID:24553140)
  4. Ma L et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 289, 12457-66 (2014)(PMID:24634219)
  5. Liu W et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 29, 1113-23 (2015)(PMID:25466893)
  6. Yanagi T et al. PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. PLoS One 10, e0119404 (2015)(PMID:25790448)
  7. Cui X et al. Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia 30, 74-85 (2016)(PMID:26220042)
  8. Tan L et al. CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells. J Virol. 90, 9782–9796 (2016)(PMID:27558422)
  9. Hashiramoto A et al. A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell. J Biol Chem. 293, 1933-1943 (2018)(PMID:29180447)
  10. Kozako T et al. Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. BMC Cancer. 18, 791 (2018)(PMID:30081901)
  11. Jing ZT et al. Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation. J Immunol. 201, 2303-2314 (2018)(PMID:30171166)
  12. Sekiguchi Y et al. The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 44, 435-440 (2019)(PMID:31168030)
  13. Liu W et al. PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury. Toxicol Appl Pharmacol. 381, 114729 (2019)(PMID:31445927)
  14. Dagenais-Lussier X et al. USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection. PLoS Pathog. 15, e1008060 (2019)(PMID:31658294)
  15. Asakawa M et al. Upregulation of Cancer-Associated Gene Expression in Activated Fibroblasts in a Mouse Model of Non-Alcoholic Steatohepatitis. Sci Rep. 9, 19601 (2019)(PMID:31862949)
  16. Masuda A et al. Efficient Recruitment of c-FLIPL to the Death-Inducing Signaling Complex Leads to Fas Resistance in Natural Killer-Cell Lymphoma. Cancer Sci. 111, 807-816 (2020)(PMID:31908105)
  17. Aoki K et al. Coordinated changes in cell membrane and cytoplasm during maturation of apoptotic bleb. Mol Biol Cell. 31, 833-844 (2020)(PMID:32049595)
  18. Thiagarajan D et al. Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms. ACR Open Rheumatol. 2, 344-356 (2020)(PMID:32392632)
  19. Graeter S et al. Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils. Front Immunol. 11, 973 (2020)(PMID:32508840)
製品
カテゴリー
分野
アポトーシス
細胞膜表面抗原
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※在庫につきましては2020年10月31日 17時00分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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