トップ > 製品検索結果一覧 > Code No. D070-5 Anti-CX3CR1 (Human) mAb-PE

Code No. D070-5

Anti-CX3CR1 (Human) mAb-PE

価格(税別)

¥48,000

在庫

10以上

(2019/12/07 00:05時点)

包装

1 mL (50 tests)

データ
  • Flow Cytometry

クローナリティー Monoclonal クローン 2A9-1
アイソタイプ
(免疫動物)
Rat IgG2bκ
使用法
FCM
20 µL (Ready for use.)  
免疫原(抗原) Human CX3CR1 expressing non-mammalian cells
交差性
[Gene ID]

Human[1524]

性状 PBS/1% BSA/0.09% NaN3
保存温度 4°C 標識 PE メーカー MBL
別称 chemokine (C-X3-C motif) receptor 1, V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1
背景 There are several subfamilies in the chemokine superfamily. In addition to CXC, CC and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes. CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor family, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion.
関連製品 D070-4 Anti-CX3CR1 (Human) mAb-FITC
D070-3 Anti-CX3CR1 (Human) mAb
D070-A48 Anti-CX3CR1 (Human) mAb-Alexa Fluor® 488
D123-3 Anti-CD184 (CXCR4) mAb
D123-4 Anti-CD184 (CXCR4) mAb-FITC
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。
  1. Darbandi-Tehrani K et al. Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays. FASEB J. 24, 4585-98 (2010)(PMID:20667981)
  1. van de Berge PJ et al. Cytomegalovirus-induced effector T cells cause endothelial cell damage. Clin. Vaccine Immunol. 19, 772-9 (2012)(PMID:22398244)
  1. de Niet E et al. Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy. J Hepatol. 64, 539-46 (2016)(PMID:26505119)

Flow Cytometry

  1. Makishima H et al. Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease. Intern Med. 47, 295-8 (2008)(PMID:18277033)
  2. Pachot A et al. Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression. J Immunol. 180, 6421-9 (2008)(PMID:18424766)
  3. Tallone T et al. Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets. J Cardiovasc Transl Res. 4, 211-9 (2011)(PMID:21308491)
  4. Hamann I et al. Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells. Immunology 133, 62-73 (2011)(PMID:21320123)
  5. Havenith SH et al. Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. Int Immunol. 24, 625-36 (2012)(PMID:22836020)
  6. Hamann I et al. Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation. J Neuroimmunol. 254, 165-9 (2013)(PMID:22948090)
  7. Bellora F et al. TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells. Eur J Immunol. 44, 1814-22 (2014)(PMID:24510590)
  8. Siddiqui I et al. Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient. J Immunother Cancer. 4, 21 (2016)(PMID:27096098)
  9. Parodi M et al. Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration. Front Immunol. 9, 2358 (2018)(PMID:30459756)
製品
カテゴリー
分野
細胞膜表面抗原
サイトカイン・増殖因子
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※在庫につきましては2019年12月07日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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