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RNAi pathway


Code No. Product name Synonyms Reactivity Applications Function, localization
RN063PW Anti-DHX9 pAb NDHII, RHA Hu/ Mo/ Ham WB/ IP DHX9 is an RNA helicase that shuttles between nucleus and cytoplasm. DHX9 is a RISC component involved in siRNA/miRNA loading onto RISC.
RN030PW Anti-DICER1 (Human) pAb DCR1, Dicer Hu WB/ IP DICER1, an endonuclease of the RNase III familiy, cleaves dsRNAs or pre-miRNA to yield siRNA or miRNA duplex. It also plays a role in loading small RNA duplex onto RISC.
RN003M Anti-EIF2C2 (AGO2) (Human) mAb AGO2 Hu WB/ IP/ RIP AGO2, a core component of RNA-induced silencing complex (RISC), plays a central role in RNAi pathway. It is reported that AGO2 is localized to P-body and involved in mRNA decay.
RN016P Anti-FMR1 pAb FMRP Hu/ Mo/ Rat WB/ IP/ RIP FMR1 contributes to binding of Dicer-processed miRNA to mRNA through interaction with Dicer and RISC.
RN125PW Anti-HENMT1 pAb HEN1, C1orf59 Hu/ Mo/ Rat WB HENMT1, small RNA 2'-O-methyltransferase, mediates stabilization of piRNA by adding 2'-O-methyl group to the 3'-end of mammalian piRNAs. HENMT1 is preferentially expressed in testis and required for mouse spermatogenesis.
RN114PW Anti-HNRNPA1 pAb   Hu/ Mo/ Rat/ Ham(w) WB/ IP HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 participates in processing by Drosha via binding to pri-miR-18 and pri-let-7a.
RN127PW Anti-NSUN2 (Human) pAb MISU, MRT5, SAKI, TRM4 Hu WB/ IP NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis.
RN009M Anti-PABPC1 mAb PABP1 Hu/ Ham WB/ IP/ RIP/ IC PABPC1 promotes miRNA-mediated translational repression and/or decay of its target mRNA via binding to GW182.
RN058PW Anti-TARBP2 pAb TRBP Hu/ Rat WB TARBP2, one of the RISC components, serves as a binding partner of Dicer. It binds to guide strand of miRNA duplex after dicing. It is reported that TARBP2 is involved in transfer of siRNA and miRNA from Dicer to AGO2.
RN107PW Anti-TARDBP (TDP-43) pAb TDP-43 Hu/ Mo/ Ham WB/ IP TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP promotes miRNA processing in both nucleus and cytoplasm as a component of Drosha and Dicer complexes.
RN033P Anti-TNRC6A (GW182) pAb GW182, GW1 Hu/ Mo/ Rat WB/ IP/ RIP/ IC* TNRC6A/GW182, associated with gene silencing by small ncRNA such as miRNA, has RNA recognition motif and several AGO binding domains. It serves as a trasnlational repressor of mRNA via binding to RISC components. It is reported that TNRC6A/GW182 is a major component of P-body/GW-body.

For applications and reactivities:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: Information from the licensor (Not tested by MBL). Please check the data sheet for detailed information.





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