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HOME > Product category > RNA-RNP Network > Regulation of stability and decay | RiboCluster Profiler

Regulation of stability and decay


Code No. Product name Synonyms Reactivity Applications Function, localization
RN032P Anti-CIRBP pAb CIRP Hu/ Mo/ Rat WB/ IP/ RIP CIRBP is involved in cold stress-induced suppression of cell proliferation. It also serves as a translational activator to promote the translation of mRNA under mild hypothermic conditions.
RN035PW Anti-CUGBP2 pAb CELF2 Hu/ Mo/ Rat/ Ham WB CUGBP2 is highly expressed in most tissues including muscle. It is involved in stabilization of COX2 mRNA via binding to 3'-UTR of the mRNA. It also induces apoptosis in tumor cells via binding to 3'-UTR of Mcl-1 mRNA.
RN063PW Anti-DHX9 pAb NDHII, RHA Hu/ Mo/ Ham WB/ IP DHX9 is an RNA helicase that shuttles between nucleus and cytoplasm. DHX9 is involved in stabilization of c-myc mRNA via asscoation with IMP1, HNRNPU, YBX1and SYNCRIP.
RN003M Anti-EIF2C2 (AGO2) (Human) mAb AGO2 Hu WB/ IP/ RIP AGO2, a core component of RNA-induced silencing complex (RISC), plays a central role in RNAi pathway. It is reported that AGO2 is localized to P-bodies and involved in mRNA decay.
RN001P Anti-EIF4E pAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ IC/ IF EIF4E, one of the translation-intiation factors, binds to m7G cap structure of eukaryotic mRNA. It is also related to mRNA export from nucleus to cytoplasm.
RN006M Anti-EIF4E mAb 　 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP EIF4E, one of the translation-intiation factor, binds to m7G cap structure of eukaryotic mRNA. It is also related to export of mRNA from nucleus to cytoplasm.
RN004P Anti-ELAVL1 (HuR) pAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ IC/ IF ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN007M Anti-ELAVL1 (HuR) mAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN005P Anti-ELAVL2 (HuB) (Human) pAb HuB Hu WB/ IP/ RIP/ IC/ IF ELAVL2/HuB, one of Hu family proteins, is specifically expressed in neuronal cells. It shuttles between nucleus and cytoplasm and regulates stabilization and translational efficiency of mRNAs via binding to AU-rich elements of them.
RN006P Anti-ELAVL3 (HuC) pAb HuC Hu/ Mo/ Rat WB/ IP/ RIP ELAVL3/HuC, a member of Hu protein family, may be related to neuronal development. It shuttles between nucleus and cytoplasm and regulates stability and translational efficiency of mRNAs via binding to AU-rich elements of them.
RN048PW Anti-G3BP1 pAb G3BP Hu WB/ IP G3BP1, a DNA/RNA helicase, is involved in stress granule formation. It also promotes mRNA decay by binding to 3'-UTR in c-Myc mRNA and stabilization of Tau mRNA.
RN125PW Anti-HENMT1 pAb HEN1, C1orf59 Hu/ Mo/ Rat WB HENMT1, small RNA 2'-O-methyltransferase, mediates stabilization of piRNA by adding 2'-O-methyl group to the 3'-end of mammalian piRNAs. HENMT1 is preferentially expressed in testis and required for mouse spermatogenesis.
RN114PW Anti-HNRNPA1 pAb 　 Hu/ Mo/ Rat/ Ham(w) WB/ IP HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 stabilizes IL2 and GM-CSF mRNA by binding to AU-rich elements in their 3'-UTR.
RN052PW Anti-HNRNPC pAb 　 Hu/ Mo WB/ IP HNRNPC binds and stabilizes APP mRNA. It also promotes translation of APP mRNA via binding to the coding region of the mRNA in competition with FMR1.
RN060PW Anti-HNRNPD (AUF1) pAb AUF1 Hu/ Mo/ Rat/ Ham WB/ IP HNRNPD regulates mRNA decay by binding to AU-rich element in the mRNA. It is also involved in translation-dependent mRNA degradation through interaction with EIF4G1 and PABP.
RN007P Anti-IGF2BP1 (IMP1) pAb ZBP1 Hu/ Mo WB/ IP/ RIP/ IC/ IF IGF2BP1 (IMP1) is involved in stabilization of c-myc mRNA via asscoation with HNRNPU, YBX1, DHX9 and SYNCRIP.
RN001M Anti-IGF2BP1 (IMP1) mAb ZBP1 Hu/ Mo WB/ IP/ RIP IGF2BP1 (IMP1) is involved in stabilization of c-myc mRNA via asscoation with HNRNPU, YBX1, DHX9 and SYNCRIP.
RN127PW Anti-NSUN2 (Human) pAb MISU, MRT5, SAKI, TRM4 Hu WB/ IP NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis.
RN009M Anti-PABPC1 mAb PABP1 Hu/ Ham WB/ IP/ RIP/ IC PABPC1 functions as a stabilizer of mRNA by binding to its poly(A) tail. PABPC1 is involved in deadenylation and degradation of its mRNA after translation termination. It has also been reported that PABPC1 plays an important role in NMD.
RN023PW Anti-PABPN1 pAb PABP2 Hu/ Mo WB/ IP PABPN1, localized to nucleus, strongly binds to poly(A) of primary mRNA after transcription. It is important to regulate the length of poly(A) tail by polyadenylation and associated with mRNA maturation.
RN024P Anti-PCBP1 pAb HNRPE1 Hu/ Mo/ Rat WB/ IP/ RIP PCBP1 is one of the major PCBP isoforms shuttling between nucleus and cytoplasm. It stabilizes target mRNAs such as α-globin and type I collagen via binding to poly(rC) and polypyrimidine.
RN025P Anti-PCBP2 pAb HNRPE2 Hu/ Mo/ Rat WB/ IP/ RIP PCBP2 binds to poly(rC) in the same way as PCBP1 and hnRNPK, and has been reported to bind to poly(rU) as well. It is localized in stress granule and P-body.
RN011P Anti-PTBP1 (Human) pAb hnRNPI Hu WB/ IP/ RIP/ IF* PTBP1 regulates the stability of mRNA such as CD40LG. It is also involved in exon inclusion in competition with other splicing repressors.
RN012P Anti-STAU1 (Human) pAb 　 Hu WB/ IP/ RIP STAU1 is a key molecule in Staufen-Mediated Decay (SMD). STAU1 recruits UFP1, an essential player of Nonsense-Mediated Decay (NMD), via binding to cis-element in the 3'-UTR of target mRNA and regulates the mRNA decay.
RN107PW Anti-TARDBP (TDP-43) pAb TDP-43 Hu/ Mo/ Ham WB/ IP TARDBP (TDP-43) is a nuclear DNA/RNA binding protein involved in mRNA splicing, nuclear export, stability, miRNA biogenesis and transcriptional repression. TARDBP is mainly localized in nucleus, but in cytoplasm in neurodegenerative diseases such as ALS.
RN033P Anti-TNRC6A (GW182) pAb GW182, GW1 Hu/ Mo/ Rat WB/ IP/ RIP/ IC* TNRC6A/GW182, associated with gene silencing by small ncRNA such as miRNA, has RNA recognition motif and several AGO binding domains. TNRC6A serves as a trasnlational repressor of mRNA via binding to RISC components. It is reported that TNRC6A is a major component of P-body/GW-body.
RN123PW Anti-YTHDF2 pAb CAHL, HGRG8, NY-REN-2 Hu/ Mo/ Rat(w)/ Ham WB/ IP YTHDF2, functioning as m6A reader protein, is involved in methylation-dependent RNA decay. Binding of YTHDF2 to m6A containing mRNAs leads to localization of the mRNAs to P-body and degradation.

For applications: *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.





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