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HOME > Product category > RNA-RNP Network > RNA modification | RiboCluster Profiler

RNA modification


Code No. Product name Synonyms Reactivity Applications Function, localization
RN126PW Anti-AHCY (SAHH) pAb

adoHcyase

Hu WB/ IP AHCY (SAHH) is the only enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine to adenosine and homocysteine. AHCY (SAHH) is involved in the regulation of intracellular methylation processes.
RN122PW Anti-ALKBH5 pAb   Hu/ Mo WB/ IP ALKBH5 is one of mammalian m6A demethylase, localized in nuclear speckles, catalyzes the direct removal of m6A modification on nuclear RNA and its demethylation affects RNA processing and RNA export.
RN125PW Anti-HENMT1 pAb HEN1, C1orf59 Hu/ Mo/ Rat WB HENMT1, small RNA 2'-O-methyltransferase, mediates stabilization of piRNA by adding 2'-O-methyl group to the 3'-end of mammalian piRNAs. HENMT1 is preferentially expressed in testis and required for mouse spermatogenesis.
RN127PW Anti-NSUN2 (Human) pAb MISU, MRT5, SAKI, TRM4 Hu WB/ IP NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis.
RN124PW Anti-RNMT (Human) pAb KIAA0398, hCMT1c, MET, RG7MT1 Hu WB/ IP RNMT, mRNA cap methyltransferase, is involved in cap formation at the 5'-end of nascent RNA via methylation of the 5'-cap.
RN128PW Anti-TRMT6 (Human) pAb KIAA1153, TRM6 Hu WB/ IP tRNA m1A58 methyltransferase (m1A58 MTase) catalyzes the conversion of A to m1A at position 58 in initiator methionyl-tRNA. Human m1A58 MTase consitis of a hetrotetramer formed by TRMT6 and TRMT61, an RNA-binding component and a catalytic component.
RN123PW Anti-YTHDF2 pAb CAHL, HGRG8, NY-REN-2 Hu/ Mo/ Rat(w)/ Ham WB/ IP YTHDF2, functioning as m6A reader protein, is involved in methylation-dependent RNA decay. Binding of YTHDF2 to m6A containing mRNAs leads to localization of the mRNAs to P-body and degradation.




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