Antibody detailed product information

Code No.	W072-3
Anti-CD358 (DR6) (Human) mAb
Size	100 µL (1 mg/mL)
Availability (in Japan)	1-9 （In Japan at 00:05, Apr 19, 2024 in JST）
Clonality	Monoclonal
Clone	3E2E4
Isotype (Immunized Animal)	Mouse IgG2aκ
Applications	FCM　1-10 µg/mL
Immunogen (Antigen)	Human CD358 (DR6) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]	Human[27242]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	TNFRSF21, BM-018
Background	Death receptor 6 (DR6), also known as CD358 or TNFRSF21, is a member of the tumor necrosis factor receptor superfamily. DR6 contains a death domain and four TNFR-Cys repeats. It is highly expressed in the heart, brain, placenta, pancreas, lymph nodes, thymus, and prostate. DR6 activates nuclear factor kappa-B and mitogen-activated protein kinase 8 and induces cell apoptosis. Overexpression of DR6 has been observed in several cancers including ovarian cancer and sarcoma.
Related products	M076-3 Mouse IgG2a (isotype control) MTG-001 Clear Back (Human Fc receptor blocking reagent) D297-3 Anti-p75NTR (Mouse) mAb M009-3 Anti-Amyloid Precursor Protein mAb W164-3 Anti-RHBDD3 (Human) mAb
Product category	Research area:Cancer Apoptosis Cell surface antigens Tools:Flow cytometry reagents
Data
References	Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)（PMID: 10331810）

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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