Code No. | PD010 | |
Anti-ATBF1 (D1-120) pAb | ||
Size | 100 µL | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, May 13, 2024 in JST) |
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Clonality | Polyclonal | |
Clone | Polyclonal | |
Isotype (Immunized Animal) |
Rabbit IgG | |
Applications | WB 1:2,000 IP 1 µL/150 µg of cell lysate IC 1:500 IH 1:2,500-1:5,000 IF 1:500 |
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Immunogen (Antigen) |
recombinant region of human ATBF1 (2107-2147 aa.) corresponding to the identical amino acid sequence of mouse ATBF1 (2114-2154 aa.) | |
Reactivity [Gene ID] | ||
Storage buffer | PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | ZFHX3, ATBT, ZNF927 | |
Background | ATBF1 (also known as ZFHX3) is a transcription factor that has two-protein isoforms, the 404 kDa ATBF1-A and the 306 kDa ATBF1-B. ATBF1-A contains four homeodomains and 23 zinc-finger motifs. ATBF1-B contains four homeodomains and 18 zinc fingers. ATBF1 is identified as DNA-binding protein, which binds to an AT-rich element of the human α-fetoprotein (AFP) gene, as a result suppressing its transcription activity. ATBF1 is also involved in cell cycle arrest and cooperating with p53 to activate the p21Waf1/Cip1 promoter. ATBF1 is expressed in the differentiation fields in association with β-tubulin III and MAP2 that are the neuronal differentiation marker. ATBF1 plays a crucial role in neuronal development and cell cycle arrest. |
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Related products | PD011 Anti-ATBF1 (AT-6) pAb |
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Product category | Research area:Cancer | |
Data | ||
Citations | Western Blotting
Immunocytochemistry
Immunohistochemistry
Immunofluorescence
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