Antibody detailed product information

Code No. MEX002-6
Anti-CD63 (LAMP-3) mAb-Biotin
Size 50 µL (1 mg/mL)
Availability (in Japan) 1-9
（In Japan at 00:05, Apr 16, 2024 in JST）
Clonality Monoclonal
Clone C047-1
Isotype
(Immunized Animal) 		Mouse IgG2bκ
Applications WB　1 µg/mL  
FCM　5 µg/mL  
ELISA　Can be used. Please refer to "ExoDiluent for Immunoassay (MEX1001)"together.  
Other(Exosome isolation)　Can be used. Please refer to "ExoCap™ Streptavidin Kit (MEX-SA)"together.  
Immunogen
(Antigen)		 Human prostate carcinoma cell line (PC3) derived exosomes (prepared by ultracentrifugation from cultured supernatant)
Reactivity [Gene ID]

Human[967]
Storage buffer 1 mg/mL in PBS/1% BSA/0.1% ProClin 950
Storage temp. 4°C
Conjugate Biotin
Manufacturer MBL
Alternative names MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29
Background CD63 antigen, also known as LAMP-3, is a tetraspanin characterized by four transmembrane domains and a member of the transmembrane 4 superfamily. CD63 is the first characterized tetraspanin. CD63 has broad tissue distribution and may play multiple roles in a variety of cellular processes such as immune response and tumorigenesis, but its function has not been elucidated entirely. It is reported that CD63 is abundant in tetraspanin-enriched microdomains (TEMs) and a certain type of cellular compartment, such as late endosomes and lysosomes, while the tetraspanin-rich small lipid bilayers are secreted into extracellular fluid as a certain type of extracellular vesicles, called exosome. Because of various exosome features, CD63, one of the representative exosome surface proteins, is thought to be related to intercellular communication.
Related products MEX001-6 Anti-CD9 mAb-Biotin
D263-3 Anti-CD63 (LAMP-3) (Mouse) mAb
M077-6 Mouse IgG2b (isotype control)-Biotin
MEX002-3 Anti-CD63 (LAMP-3) mAb
MEX002-6 Anti-CD63 (LAMP-3) mAb-Biotin
MEX003-3 Anti-CD81 (TAPA1) mAb
MEX003-6 Anti-CD81 (TAPA1) mAb-Biotin
3190 Magnetic Rack
MEX001-3 Anti-CD9 mAb
MEX001-4 Anti-CD9 mAb-FITC
MEX002-4 Anti-CD63 (LAMP-3) mAb-FITC
MEX003-4 Anti-CD81 (TAPA1) mAb-FITC
MEX001-12 Anti-CD9 mAb-ALP
MEX002-12 Anti-CD63 (LAMP-3) mAb-ALP
MEX003-12 Anti-CD81 (TAPA1) mAb-ALP
Product category Research area:RNA-RNP Network Cancer Cell surface antigens Exosomes
Data




References
  1. Mitsunari T et al. Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol. 25, 9318-23 (2005)（PMID: 16227583）
  2. Nishida K et al. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol. 170, 115-26 (2005)（PMID: 15998803）
  3. Kabu K et al. Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol. 177, 1296-1305 (2006)（PMID: 16818790）
  4. Liu Y et al. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med. 204, 93-103 (2007)（PMID: 17190838）
  5. Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol. 21, 575-81 (2009)（PMID: 19442504）
  6. Pols MS, Klumperman J. Trafficking and function of the tetraspanin CD63. Exp Cell Res. 315, 1584-92 (2009)（PMID: 18930046）
  7. Yoshioka Y et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun. 5, 3591 (2014)（PMID: 24710016）
  8. Melo SA et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177-82 (2015)（PMID: 26106858）
  • The availability is based on the information in Japan at 00:05, Apr 16, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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