Antibody detailed product information

Code No. MD-10-4
Anti-Fas (CD95) (Human) mAb-FITC
Size 100 µL (500 µg/mL)
Availability (in Japan) 10 or more
（In Japan at 17:00, Apr 16, 2024 in JST）
Clonality Monoclonal
Clone UB2
Isotype
(Immunized Animal) 		Mouse IgG1
Applications FCM　10 µg/mL  
Immunogen
(Antigen)		 Recombinant Human Fas
Reactivity [Gene ID]

Human[355], Mouse(-)
Storage buffer 500 µg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C
Conjugate FITC
Manufacturer MBL
Alternative names APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.
Related products SY-001 Anti-Fas (CD95) (Human) mAb
MD-10-3 Anti-Fas (CD95) (Human) mAb
MD-10-5 Anti-Fas (CD95) (Human) mAb-PE
MD-10-A48 Anti-Fas (CD95) (Human) mAb-Alexa Fluor™ 488
MD-11-3 Anti-Fas (CD95) (Human) mAb
M075-4 Mouse IgG1 (isotype control)-FITC
Product category Research area:Apoptosis Cell surface antigens
Data

Citations

Flow Cytometry

  1. Yanagisawa J et al. The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. J Biol Chem. 272, 8539-45 (1997)(PMID:9079683)
  2. Koshiji M et al. Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and/or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2. Clin Exp Immunol. 111, 211-8 (1998)(PMID:9472684)
  3. Sata M et al. Oxidized LDL activates fas-mediated endothelial cell apoptosis. J Clin Invest. 102, 1682-9 (1998)(PMID:9802882)
  4. Matsumoto Y et al. Peripheral deletion of gammadelta T cells in haemodialysis patients. Nephrol Dial Transplant. 13, 2861-6 (1998)(PMID:9829491)
  5. Morimoto Y et al. Functional expression of Fas and Fas ligand on human intestinal intraepithelial lymphocytes. Clin Exp Immunol. 116, 84-9 (1999)(PMID:10209509)
  6. Ohashi M et al. Changes in susceptibility to Fas-mediated apoptosis during differentiation of HL-60 cells. J Leukoc Biol. 67, 374-80 (2000)(PMID:10733098)
  7. Shinohara H et al. Fas drives cell cycle progression in glioma cells via extracellular signal-regulated kinase activation. Cancer Res. 60, 1766-72 (2000)(PMID:10749152)
  8. Yuki H et al. A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines. Free Radic Res. 37, 631-43 (2003)(PMID:12868490)
  9. Yamauchi R et al. Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis. J Invest Dermatol. 122, 477-83 (2004)(PMID:15009733)
  10. Hamasu T et al. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists. J Radiat Res. 46, 103-10 (2005)(PMID:15802865)
  11. Ennaciri J et al. Induction of apoptosis by herpes simplex virus-1 in neonatal, but not adult, neutrophils. Pediatr Res. 59, 7-12 (2006)(PMID:16327000)
  12. Tanaka T et al. Differential sensitivity to paclitaxel-induced apoptosis and growth suppression in paclitaxel-resistant cell lines established from HEC-1 human endometrial adenocarcinoma cells. Int J Oncol. 41, 1837-44 (2012)(PMID:22923148)
  13. Villa-Morales M et al. FAS system deregulation in T-cell lymphoblastic lymphoma.colorectal cancer. Cell Death Dis. 5, e1110 (2014)(PMID:24603338)
  • The availability is based on the information in Japan at 17:00, Apr 16, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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