Code No. | D092-3M2 | |
Anti-CD274 (PD-L1) (Human) mAb (Functional Grade) | ||
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, Apr 19, 2024 in JST) |
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Clonality | Monoclonal | |
Clone | MIH3 | |
Isotype (Immunized Animal) |
Mouse IgG1 | |
Applications | FCM 5-10 µg/mL Other(Adhesion Assay ) reported. (PMID: 18585785) |
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Immunogen (Antigen) |
L cells transfected full length human PD-L1 protein | |
Reactivity [Gene ID] | Human[29126] |
|
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 | |
Background | Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitrostudy indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-g GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable. | |
Related products | D092-3 Anti-CD274 (PD-L1) (Human) mAb D230-3 Anti-CD274 (PD-L1) (Human) mAb D230-5 Anti-CD274 (PD-L1) (Human) mAb-PE D133-3M2 Anti-CD279 (PD-1) (Human) mAb (Functional Grade) M075-3M2 Mouse IgG1 (isotype control) (Functional Grade) |
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Product category | Research area:Immunology Cell surface antigens | |
Data |