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HOME > Product search results > Code No. RN115PW Anti-LIN28B (Human) pAb

Code No. RN115PW

Anti-LIN28B (Human) pAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 23, 2017 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunoprecipitation

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:1,000  
IP
5 μL/500 μL of cell extract from 1 x 107 cells  
Reactivity [Gene ID]

Human[2107 ], Mouse(-)[225363 ], Rat(-)[307503 ], Hamster(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names lin-28 homolog B (C. elegans), CSDD2
Background LIN28A and LIN28B are developmentally regulated RNA-binding proteins that function as inhibitors of miRNA-mediated translational control via blocking the production of let-7 miRNA in embryonic stem cells. LIN28A predominantly presents in cytoplasm and inhibits pre-let-7 processing by DICER via recruiting TUTase that uridylates pre-let-7 and induces its degradation, whereas LIN28B, which can accumulate in nucleus, directly binds to pri-let-7 and suppresses its processing by DROSHA. Overexpression of LIN28A and LIN28B contribute to tumorigenesis and metastasis in various cancers. It has been reported that LIN28B is up-regulated and promotes progression and metastasis in poor prognosis patients with colon, liver, esophageal cancers and neuroblastoma.
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Product category
Research area
Stem cell research
RNA-RNP Network
Cancer
Brands
RiboCluster Profiler™
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Nov 23, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.