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HOME > Product search results > Code No. RN034PW Anti-CUGBP1 pAb

Code No. RN034PW

Anti-CUGBP1 pAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 24, 2017 in JST)

Size

100 µL

Data
  • Western Blotting

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1 µg/mL  
IC*
reported.  (PMID: 26990993
Immunogen (Antigen) KLH conjugated synthetic peptide, corresponding to N-terminus of human CUGBP1
Reactivity [Gene ID]

Human[10658], Mouse[13046], Rat[362160], Hamster[100760547]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names CELF1, CUG-BP1, BRUNOL2, CUG-BP, CUGBP, NAB50, hNab50
Background CUG-binding protein 1 (CUG-BP1) was the first discovered member of the CUG-BP1 and ETR-3-like factors (CELF) family. All CELF proteins possess the same domain structure comprising 3 RNA recognition motifs (RRMs) and a divergent hinge region of 60&ndash;90 residues between RRM2 and RRM3. CUG-BP1 performs various functions in posttranscriptional gene regulation, including alternative splicing, translation, and deadenylation. It has been reported that CUG-BP1 plays a role in the pathogenesis of the trinucleotide expansion disease, namely, myotonic dystrophy (DM1), in that it is associated with (CTG)<em>n</em> repeat expansion in the 3&prime; UTR of myotonin protein kinase (Mt-PK) gene. The (CUG)<em>n</em> repeat region in Mt-PK mRNA is the binding site for CUG-BP1, and the triplet repeat expansion sequesters CUG-BP1 on mutant Mt-PK mRNAs. Recent studies have demonstrated that CUG-BP1 has stronger affinity toward UG repeats than CUG repeats. Since UG repeats are enriched in short-lived transcripts, CUG-BP1 was suggested to be a mediator of UG-motifs-dependent mRNA decay.
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Citations

Immunocytochemistry

  1. Sundararaman B et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 61, 903-13 (2016)(PMID:26990993)
Product category
Research area
RNA-RNP Network
Neuroscience
Brands
RiboCluster Profiler™
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  • The availability is based on the information in Japan at 01:30, Nov 24, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.