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HOME > Product search results > Code No. RN028PW Anti-EIF2C1 (AGO1) pAb

Code No. RN028PW

Anti-EIF2C1 (AGO1) pAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 24, 2017 in JST)

Size

100 µL

Data
  • Western Blotting

  • Immunoprecipitation

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:1,000  
IP
5 µL/500 µL of cell extract from 5 x 106 cells  
IC*
reported.  (PMID: 26990993
Immunogen (Antigen) KLH conjugated synthetic peptide, corresponding to N-terminus of human EIF2C1
Reactivity [Gene ID]

Human[26523], Mouse[236511], Rat(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names argonaute RISC catalytic component 1, Q99
Background Eukaryotic translation initiation factor 2C, subunit 1 (EIF2C1; AGO1) is a member of the argonaute protein family. It contains Piwi/Argonaute/Zwille (PAZ) and Piwi domain. EIF2C1 and EIF2C2 form the RNA-induced silencing complex that mediates gene silencing by RNA interference. EIF2C1 is also known as the initiator of RNA-induced transcriptional gene silencing (TGS) in human cells. EIF2C1, DNA methyltransferase 3a, and histone deacetylase I form the transcriptional silencing complex. EIF2C1 binds to RNA polymerase II and mediates TGS through heterochromatin formation. In humans, the gene encoding EIF2C1 is localized on chromosome 1; this region is often deleted in cases of Wilms’ tumors. EIF2C1 may be involved in tumor development because its expression is upregulated in tumors that lack the Wilm’s tumor suppressor gene, namely, WT1.
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Citations
  1. Wang D et al. Quantitative functions of Argonaute proteins in mammalian development. Genes Dev. 26, 693-704 (2012)(PMID:22474261)
  1. Tattikota SG et al. Argonaute2 regulates the pancreatic β-cell secretome. Mol Cell Proteomics. 12, 1214-25 (2013)(PMID:23358505)
  1. Lewkowicz P et al. Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination. J Neurosci. 35, 7521-37 (2015)(PMID:25972178)
  1. Yamagishi M et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 5, 17868 (2015)(PMID:26639163)

Immunocytochemistry

  1. Sundararaman B et al. Resources for the Comprehensive Discovery of Functional RNA Elements. Mol Cell. 61, 903-13 (2016)(PMID:26990993)
Product category
Research area
RNA-RNP Network
Brands
RiboCluster Profiler™
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Nov 24, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.