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HOME > Product search results > Code No. RN012P Anti-STAU1 (Human) pAb

Code No. RN012P

Anti-STAU1 (Human) pAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 23, 2017 in JST)

Size

200 µg/200 µL

Data
  • Western Blotting

  • Immunoprecipitation

  • RNP Immunoprecipitation

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:1,000  
IP
1.5 μL/50 μL of cell extract from 1.25 x 106 cells  
RIP
15 μg/500 μL of cell extract from 1.5 x 107 cells  
Immunogen (Antigen) KLH-conjugated synthetic peptide MKLGKKPMYKPVDPYSRMQ (82-100 aa)
Reactivity [Gene ID]

Human[6780](22584570), Mouse(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names staufen double-stranded RNA binding protein 1, STAU
Background Mammalian Staufen1 (Stau1) is a ubiquitous double-stranded RNA binding protein associated with polysomes. It has two protein isoforms, molecular weights of 55 and 63 kDa. The 55 kDa isoform associates with 40S and 60S ribosomal subunit and colocalizes with the rough endoplasmic reticulum. Stau1 is thought to function in transporting mRNA, controlling and eliciting mRNA decay. Previous study showed that the Stau1 recruits upf1 to 3' UTR region of Arf1 mRNA and induces the Stau1-mediated mRNA decay (SMD). Recent study suggests that Stau1 regulates diverse class of mammalian transcripts. In order to identify mRNA targets of Staufen proteins, RIP-Assay technology was employed and identified distinct but overlapping subset of cellular mRNAs associated with Stau1 and Stau2-containing ribonucleoprotein complexes.
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Citations

RNP Immunoprecipitation

  1. Ramen AV et al. Selenoprotein W expression and regulation in mouse brain and neurons. Brain Behav. 3, 562-74 (2013)
  2. Yu Z et al. Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. J Biol Chem. 287, 22560-72 (2012)(PMID:22584570)
Product category
Research area
RNA-RNP Network
Neuroscience
Brands
RiboCluster Profiler™
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Nov 23, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.