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HOME > Product search results > Code No. RN001M Anti-IGF2BP1 (IMP1) mAb

Code No. RN001M

Anti-IGF2BP1 (IMP1) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 24, 2017 in JST)

Size

200 µg/200 µL

Data
  • Western Blotting

  • Immunoprecipitation

  • RNP Immunoprecipitation

Clonality Monoclonal Clone 6H6
Isotype (Immunized Animal) Mouse IgG2aκ
Applications
WB
1 μg/mL  
IP
5 μg/500 μL of cell extract from 5 x 106 cells  
RIP
15 μg/500 μL of cell extract from 1 x 107 cells  
Immunogen (Antigen) Recombinant full length IGF2BP1
Reactivity [Gene ID]

Human[10642], Mouse[140486]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names insulin-like growth factor binding protein 1, CRD-BP, CRDBP, IMP-1, VICKZ1, ZBP1
Background Localization of IGF2 mRNA-binding protein 1 (IMP1) is associated with motility, and the major functions of IMP1 are carried out by the phylogenetically conserved K homology (KH) domains. IMP1 can affect stability, localization, and translation of its target RNAs. Binding of IMP1 to the leader 3 mRNA in the 5’-untranslated region (UTR) of IGF2 inhibits translation from a leader 3 reporter mRNA. Aberrant IMP1 expression may interfere with c-myc regulation. In tumors, gains at 8q24 (c-myc locus) were observed to be more frequent than those at 17q21 (IMP1 locus). Furthermore, IMP1 expression was frequently detected in tumors, implying that the mechanism of activation is other than that of gene amplification.
Related products RN1001 RIP-Assay Kit
RN1005 RIP-Assay Kit for microRNA
RN007P Anti-IGF2BP1 (IMP1) pAb
RN008P Anti-IGF2BP2 (IMP2) pAb
RN009P Anti-IGF2BP3 (IMP3) pAb
RN048PW Anti-G3BP1 pAb
Citations

Western Blotting

  1. Cassar PA et al. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. EMBO Rep. 16, 1334-57 (2015)(PMID:26265008)
Product category
Research area
RNA-RNP Network
Cancer
Neuroscience
Brands
RiboCluster Profiler™
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  • The availability is based on the information in Japan at 01:30, Nov 24, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.