Anti-ZBTB24 pAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 19, 2024 in JST）

Size

100 µL

Citations

Data Sheet

SDS

This antibody is suitable for detecting mouse ZBTB24 protein.

Data	Western Blotting Immunoprecipitation
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Guinea pig Ig (aff.)
Applications	WB 1:1,000 IP 2 µL/300 µL of cell extract from 1 x 10⁶ cells/sample ※ Not recommended for human samples
Immunogen (Antigen)	Recombinant mouse ZBTB24 (C-terminus)
Reactivity [Gene ID]	Human[9841], Mouse[268294]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	BIF1, ICF2, PATZ2, KIAA0441, ZNF450
Background	ZBTB24 is a member of the Zinc finger and BTB domain-containing protein family. ZBTB24 consists of a BTB domain, an AT-hook DNA binding motif, and 8 C2H2-type zinc fingers. Mutations in the ZBTB24 gene are responsible for type 2 ICF (Immunodeficiency, Centromeric instability and Facial anomalies) syndrome, which shows hypomethylation of centromeric and pericentromeric satellite repeats. Because ZBTB24 localizes to pericentromeric heterochromatin, this protein may play an important role in formation and/or maintenance of pericentromeric heterochromatin.
Related products	PM086 Anti-ZBTB24 (Human) pAb D346-3 Anti-5-methylcytidine (m⁵C) mAb M218-3 Anti-5-hydroxymethylcytosine (5hmC) mAb PM077 Anti-5-hydroxymethylcytosine (5hmC) pAb M202-3 Anti-Np95 (Uhrf1) mAb D289-3 Anti-Np95 (Uhrf1) (Mouse) mAb PM067 Normal Guinea Pig IgG
Citations	Western Blotting Wu H et al. Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals. Hum Mol Genet. (2016) In press.(PMID:27466202)
References	Nitta H et al. J Hum Genet. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. J Hum Genet. 58, 455-60 (2013)（PMID: 23739126） Weemaes CM et al. Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects. Eur J Hum Genet. 21, 1219-25 (2013)（PMID: 23486536） Cerbone M et al. Immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome, due to ZBTB24 mutations, presenting with large cerebral cyst. Am J Med Genet A. 158A, 2043-6 (2012)（PMID: 22786748） Chouery E et al. A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Clin Genet. 82, 489-93 (2012)（PMID: 21906047） de Greef JC et al. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am J Hum Genet. 88, 796-804 (2011)（PMID: 21596365）
Product category	Research area Epigenetics

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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