Anti-Phospho-p62 (SQSTM1) (Ser351) mAb

Availability (in Japan)

1-9

（In Japan at 17:00,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting Immunocytochemistry Immunohistochemistry
Clonality	Monoclonal	Clone	5D5
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 0.5 µg/mL IC 0.1 µg/mL IH 1 µg/mL
Immunogen (Antigen)	KLH conjugated synthetic peptide, CKEVDP(pS)TGELQSLQ (corresponding to amino acid residues 346-359 of mouse p62 (SQSTM1))
Reactivity [Gene ID]	Human[8878], Mouse[18412], Rat**
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1, ORCA, OSIL
Related products	PM066 Anti-p62 C-terminal pAb PM074 Anti-Phospho-p62 (SQSTM1) (Ser351) pAb D343-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb D344-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb PM045 Anti-p62 (SQSTM1) pAb M162-3 Anti-p62 (SQSTM1) (Human) mAb M162-A48 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 488 M162-A59 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 594 M162-A64 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 647 8485 Autophagy Ab Sampler Set M162-3 Anti-p62 (SQSTM1) (Human) mAb 8486 Autophagy Watch M217-3MS Anti-Phospho-p62 (SQSTM1) (Ser351) mAb for My select sampler set M224-3 Anti-KEAP1 mAb CY-7055 CycLex^® Total p62 ELISA Kit
Citations	Western Blotting Santarino IB et al. Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis. Sci Rep. 7, 5812 (2017)(PMID:28724916) Inoue H et al. Iron deficiency induces autophagy and activates Nrf2 signal through modulating p62/SQSTM. Biomed Res. 38, 343-350 (2017)(PMID:29225212) Immunocytochemistry Watanabe Y et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy 13, 133-148 (2017)(PMID:27846364) Santarino IB et al. Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis. Sci Rep. 7, 5812 (2017)(PMID:28724916) Immunohistochemistry Yamashita S et al. CYLD dysregulation in pathogenesis of sporadic inclusion body myositis. Sci Rep. 9, 11606 (2019)(PMID:31406156) Wang Z et al. The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance. Thorac Cancer. 11, 130-139 (2019) (PMID:31755241)
References	Ichimura Y et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51, 618-31 (2013)（PMID: 24011591） Kageyama S et al. Proteasome dysfunction activates autophagy and the keap1-nrf2 pathway. J Biol Chem. 289, 24944-55 (2014)（PMID: 25049227）
Product category	Research area Autophagy

The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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