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HOME > Product search results > Code No. W357-3 Anti-CD105 (Endoglin) (Human) mAb

Code No. W357-3

Anti-CD105 (Endoglin) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Oct 22, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 3G4A6
Isotype (Immunized Animal) Mouse IgG2bκ
Applications
FCM
1-10 µg/mL  
Immunogen (Antigen) Human CD105 (Endoglin) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]

Human[2022]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names END, HHT1, ORW1
Background Endoglin, also known as CD105, is a type I membrane protein. Endoglin is a major glycoprotein located on the cell surface of vascular endothelium. It is involved in regulation of angiogenesis. In cancer tissue, endoglin is over-expressed in proliferating endothelial cells which line tumor blood vessels. Moreover, tumor cells also express endoglin in prostate cancer and melanoma. Endoglin might be a good candidate to be used for tumor imaging and for targeted cancer therapy.
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References
  1. Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)
  2. Castonguay R et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 286, 30034-46 (2011)
  3. Chen Y et al. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 66, 19-27 (2009)
  4. Lee NY et al. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem. 283, 32527-33 (2008)
  5. Bellón T et al. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol. 23, 2340-5 (1993)
Product category
Research area
Cancer
Tools
Flow cytometry reagents
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  • The availability is based on the information in Japan at 01:30, Oct 22, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.