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HOME > Product search results > Code No. W253-3 Anti-Glypican 1 (Human) mAb

Code No. W253-3

Anti-Glypican 1 (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
May 24, 2017 in JST)

Size

100 µL: 1 mg/mL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 12C1E2F
Isotype (Immunized Animal) Mouse IgG1κ
Applications
FCM
1-10 µg/mL  
Immunogen (Antigen) Human Glypican 1 expressed Ba/F3transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]

Human[2817]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names GPC1
Background Glypican 1 (GPC1) is a member of cell surface heparan sulfate proteoglycan family. GPC1 is a GPI-anchored type membrane protein and probably involves in the control of cell division and growth regulation. GPC1 also associates with fibrillar APP A-beta peptides in lipid rafts in Alzheimer disease brains. In pancreatic ductal adenocarcinoma, enhanced GPC1 expression is suggested to correlate with BMP and activin receptors. Down-regulation of GPC1 results in suppression of pancreatic cancer cell growth.
Related products W147-3 Anti-TYRO3 (Human) mAb
W164-3 Anti-RHBDD3 (Human) mAb
M075-3 Mouse IgG1 (isotype control)
MTG-001 Clear Back (Human Fc receptor blocking reagent)
References
  1. Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)(PMID: 10331810
  2. Cheng F et al. Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. J Biol Chem. 286, 27559-72 (2011)(PMID: 21642435
  3. Svensson G, Mani K. S-Nitrosylation of secreted recombinant human glypican-1. Glycoconj J. 26, 1247-57 (2009)(PMID: 19479373
  4. Mani K et al. Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. Glycobiology 16, 1251-61 (2006)(PMID: 16971378
  5. Watanabe N et al. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J. 18, 1013-5 (2004)(PMID: 15084524
  6. Vermeesch SA et al. Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization. Genomics 25, 327-9 (1995)(PMID: 7774946
  7. David G et al. Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts. J Cell Biol. 111, 3165-76 (1990)(PMID: 2148568
Product category
Research area
Cancer
Tools
Flow cytometry reagents
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, May 24, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.