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HOME > Product search results > Code No. W124-3 Anti-GPR56 (Human) mAb

Code No. W124-3

Anti-GPR56 (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Aug 17, 2017 in JST)

Size

100 µL: 1 mg/mL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 1B9B5M
Isotype (Immunized Animal) Mouse IgG1κ
Applications
FCM
1-10 µg/mL  
Immunogen (Antigen) Human GPR56 expressed Ba/F3transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]

Human[9289]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names BFPP; TM7LN4; TM7XN1
Background GPR56 is a member of G-Protein Coupled Receptor family. GPR56 contains 7 transmembrane domains as well as a mucin-like domain and cysteine box in the N-terminal region. Distribution of human GPR56 is a wide range of different tissues including heart, kidney, testis, pancreas, thyroid gland, and skeletal muscle. GPR56 is involved in cell adhesion and probably in cell-cell interaction. GPR56 also functions antagonistically to regulate VEGF production and possibly tumor angiogenesis. It is reported that overexpression of GPR56 suppresses tumor growth and metastasis, whereas reduced expression of GPR56 enhances tumor progression.
Related products W125-3 Anti-GPR56 (Human) mAb
M075-3 Mouse IgG1 (isotype control)
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W147-3 Anti-TYRO3 (Human) mAb
W164-3 Anti-RHBDD3 (Human) mAb
References
  1. Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)(PMID: 10331810
  2. Paavola KJ et al. The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity. J Biol Chem. 286, 28914-21 (2011)(PMID: 21708946
  3. Yang L et al. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res.  71, 5558-68 (2011)(PMID: 21724588
  4. Kim JE et al. Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. J Cancer Res Clin Oncol. 136, 47-53 (2010)(PMID: 19572147
  5. Xu L et al. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. PNAS 103, 9023-8 (2006)(PMID: 16757564
Product category
Research area
Cancer
Tools
Flow cytometry reagents
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Aug 17, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.