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HOME > Product search results > Code No. SY-001 Anti-Fas (CD95) (Human) mAb

Code No. SY-001

Anti-Fas (CD95) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Mar 24, 2018 in JST)


50 µg/100 µL

Clonality Monoclonal Clone CH-11
Isotype (Immunized Animal) Mouse IgM
20 µg/mL  
20 µg/mL (final conc.)  
 Induction of apoptosis  
Immunogen (Antigen) human diploid fibroblast FS-7 cell line
Reactivity [Gene ID]

Human[355], Mouse(-)

Storage buffer 500 µg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names FAS1, APT1, TNFRSF6, APO-1, FASTM, ALPS1A
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.
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  1. Zanin-Zhorov A et al. Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells. J Immunol. 171, 5882-9 (2003)(PMID:14634098)
  2. López-Huertas MR et al. The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production. J Biol Chem. 288, 7626-44 (2013)(PMID:23364796)
  3. Murthy A et al. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506, 456-62 (2014)(PMID:24553140)
  4. Ma L et al. A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 289, 12457-66 (2014)(PMID:24634219)
  5. Liu W et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 29, 1113-23 (2015)(PMID:25466893)
  6. Yanagi T et al. PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines. PLoS One 10, e0119404 (2015)(PMID:25790448)
  7. Cui X et al. Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability. Leukemia 30, 74-85 (2016)(PMID:26220042)
  8. Tan L et al. CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells. J Virol. 90, 9782–9796 (2016)(PMID:27558422)
  9. Hashiramoto A et al. A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell. J Biol Chem. 293, 1933-1943 (2018)(PMID:29180447)
Product category
Research area
Cell surface antigens

  • The availability is based on the information in Japan at 01:30, Mar 24, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.