Anti-p62 C-terminal pAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

100 µL

Citations

Data Sheet

SDS

Data	Western Blotting Immunoprecipitation Immunocytochemistry Immunohistochemistry
Clonality	Polyclonal	Clone	Polyclonal
Isotype (Immunized Animal)	Guinea pig Ig (aff.)
Applications	WB 1:1,000 IP 5 µL/300 µL of cell extract from 3x10⁶ cells IC 1:500 IH 1:100
Immunogen (Antigen)	Human p62 C-terminal peptide
Reactivity [Gene ID]	Human[8878], Mouse[18412], Rat[113894], Hamster[100768352]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	SQSTM1, sequestosome 1, p62
Background	p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain. This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency.
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Citations	Western Blotting Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238) De Pace R et al. Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome. PLoS Genet. 14, e1007363 (2018)(PMID:29698489) Qian Q et al. Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity. Cell Mol Gastroenterol Hepatol. 8, 95-110 (2019)(PMID:30926581) Sakai H et al. Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice. Toxicol Appl Pharmacol. 403, 115165 (2020)(PMID:32738330) Immunocytochemistry Matsumoto G et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 8, 9585 (2018)(PMID:29941919) Manirujjaman M et al. Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy. Cells. 9, 218 (2020)(PMID:31952347) Yamamoto YH et al. ERdj8 governs the size of autophagosomes during the formation process. J Cell Biol. 219, e201903127 (2020)(PMID:32492081) Immunohistochemistry Kimura H et al. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2, e89462 (2017)(PMID:28097232) Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238)
Product category	Research area Autophagy

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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