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HOME > Product search results > Code No. MEX002-3 Anti-CD63 (LAMP-3) mAb

Code No. MEX002-3

Anti-CD63 (LAMP-3) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
May 23, 2017 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

    non-reducing condition

  • Immunoprecipitation

  • Immunoprecipitation

  • Immunoprecipitation

    under evaluation

  • Flow Cytometry

  • Flow Cytometry

  • ELISA

    under evaluation

Clonality Monoclonal Clone C047-1
Isotype (Immunized Animal) Mouse IgG2bκ
Applications
WB
1 µg/mL (non-reducing condition)  
IP
5 µg/sample  
FCM
10 µg/mL (final concentration)  
ELISA
Can be used.  
Immunogen (Antigen) human prostate carcinoma cell line (PC3) derived exosomes (prepared by ultracentrifugation from cultured supernatant)
Reactivity [Gene ID]

Human[928], Monkey[103238483 ]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29
Background CD63 antigen, also known as LAMP-3, is a tetraspanin characterized by four transmembrane domains and a member of the transmembrane 4 superfamily. CD63 is the first characterized tetraspanin. CD63 has broad tissue distribution and may play multiple roles in a variety of cellular processes such as immune response and tumorigenesis, but its function has not been elucidated entirely. It is reported that CD63 is abundant in tetraspanin-enriched microdomains (TEMs) and a certain type of cellular compartment, such as late endosomes and lysosomes, while the tetraspanin-rich small lipid bilayers are secreted into extracellular fluid as a certain type of extracellular vesicles, called exosome. Because of various exosome features, CD63, one of the representative exosome surface proteins, is thought to be related to intercellular communication.
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MEX002-3 Anti-CD63 (LAMP-3) mAb
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3190 Magnetic Rack
MJS002V2 Protein G-Magnetic Beads
MEX001-6 Anti-CD9 mAb-Biotin
MEX002-6 Anti-CD63 (LAMP-3) mAb-Biotin
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MEX004-6 Anti-CD326 (EpCAM) mAb-Biotin
MEX1001 ExoDiluent for Immunoassay
MEX001-3 Anti-CD9 mAb
MEX001-4 Anti-CD9 mAb-FITC
MEX002-4 Anti-CD63 (LAMP-3) mAb-FITC
MEX003-4 Anti-CD81 (TAPA1) mAb-FITC
MEX001-12 Anti-CD9 mAb-ALP
MEX002-12 Anti-CD63 (LAMP-3) mAb-ALP
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References
  1. Mitsunari T et al. Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol. 25, 9318-23 (2005)(PMID: 16227583
  2. Nishida K et al. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol. 170, 115-26 (2005)(PMID: 15998803
  3. Kabu K et al. Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol. 177, 1296-1305 (2006)(PMID: 16818790
  4. Liu Y et al. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med. 204, 93-103 (2007)(PMID: 17190838
  5. Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol. 21, 575-81 (2009)(PMID: 19442504
  6. Pols MS, Klumperman J. Trafficking and function of the tetraspanin CD63. Exp Cell Res. 315, 1584-92 (2009)(PMID: 18930046
  7. Yoshioka Y et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun. 5, 3591 (2014)(PMID: 24710016
  8. Melo SA et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177-82 (2015)(PMID: 26106858
Product category
Research area
Immunology
RNA-RNP Network
Cancer
Cell surface antigens
Exosomes
Brands
ExoCap™
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, May 23, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.