This site is for customers in Asia. Customers in China & other regions, please go to Global page.
HOME > Product search results > Code No. MD-11-3 Anti-Fas (CD95) (Human) mAb

Code No. MD-11-3

Anti-Fas (CD95) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Jul 19, 2018 in JST)

Size

100 µg/100 µL

Clonality Monoclonal Clone ZB4
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
5 µg/mL  
FCM
5-20 ug/mL (final concentration)  
Immunogen (Antigen) Recombinant Human Fas
Reactivity [Gene ID]

Human[355]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Fas (TNF receptor superfamily, member 6), APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-Fas antibody (clone CH-11) is known as the agonistic antibody.
Related products SY-001 Anti-Fas (CD95) (Human) mAb
D026-3 Anti-Fas (CD95) (Mouse) mAb
MD-10-3 Anti-Fas (CD95) (Human) mAb
MD-10-4 Anti-Fas (CD95) (Human) mAb-FITC
D027-3 Anti-Fas (CD95) (Mouse) mAb
MD-10-5 Anti-Fas (CD95) (Human) mAb-PE
D041-3 Anti-Fas Ligand (CD178) (Human) mAb
D041-4 Anti-Fas Ligand (CD178) (Human) mAb-FITC
D041-5 Anti-Fas Ligand (CD178) (Human) mAb-PE
D041-6 Anti-Fas Ligand (CD178) (Human) mAb-Biotin
D042-3 Anti-Fas Ligand (CD178) (Human) mAb
D057-3 Anti-Fas Ligand (CD178) (Mouse) mAb
D057-4 Anti-Fas Ligand (CD178) (Mouse) mAb-FITC
D057-6 Anti-Fas Ligand (CD178) (Mouse) mAb-Biotin
D069-3 Anti-Fas Ligand (CD178) (Mouse) mAb
Citations
  1. Zanin-Zhorov A et al. Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells. J Immunol. 171, 5882-9 (2003)(PMID:14634098)

Western Blotting

  1. Liu W et al. Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression. FASEB J. 29, 1113-23 (2015)(PMID:25466893)

Neutralization

  1. Chiou SH et al. Up-regulation of Fas ligand expression by human cytomegalovirus immediate-early gene product 2: a novel mechanism in cytomegalovirus-induced apoptosis in human retina. J Immunol. 167, 4098-103 (2001)(PMID:11564832)
  2. Chiou SH et al. The immediate early 2 protein of human cytomegalovirus (HCMV) mediates the apoptotic control in HCMV retinitis through up-regulation of the cellular FLICE-inhibitory protein expression. J Immunol. 177, 6199-206 (2006)(PMID:17056549)
Product category
Research area
Apoptosis
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Jul 19, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.