Data |
Western Blotting
|
Clonality |
Monoclonal
|
Clone |
3D12 |
Isotype
(Immunized Animal)
|
Mouse IgG2a
|
Applications |
- WB
- 1 µg/mL
- IP
- 5 μg/2 μL of human serum
- IH
- reported.
|
Immunogen
(Antigen) |
Recombinant Human Apolipoprotein E3
|
Reactivity
[Gene ID] |
Human[348], Mouse(-), Rat(-), Rabbit(-), Bovine(-) |
Storage buffer |
1 mg/mL in PBS/50% glycerol, pH 7.2
|
Storage temp. |
-20°C
|
Conjugate |
Unlabeled |
Manufacturer |
MBL |
Alternative names |
APOE
|
Background |
Apolipoprotein E (ApoE), a 35 kDa plasma protein containing sialic acid, plays a role in triglyceride, cholesterol transport and metabolism, and known to be synthesized in liver, brain and other organs. ApoE is a polymorphic apolipoprotein exhibiting three isoforms such as Apo E2, E3 and E4 coded for by three alleles of ε2, ε3 and ε4 at a single gene locus respectively. |
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|
Citations |
Western Blotting - He X et al. Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production. J Neurosci. 27, 4052-60 (2007)(PMID:17428983)
Lindén M et al. Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer. Proteomics 12, 135-44 (2012)(PMID:22065568)
Immunohistochemistry Lindén M et al. Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer. Proteomics 12, 135-44 (2012)(PMID:22065568) - Lindén M et al. Tumour expression of bladder cancer-associated urinary proteins. BJU Int. 112, 407-15 (2013)(PMID:23470167)
- Zhang G et al. Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature. Diagn Pathol. 9, 200 (2014)(PMID:25387487)
- Levy O et al. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Mol Med. 7, 211-26 (2015)(PMID:25604058)
- Furuya H et al. Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma. Diagnostics (Basel) 10, 14 (2019)
(PMID:31905599)
|
Product category |
- Research area
- Neuroscience
|