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HOME > Product search results > Code No. M021-3 Anti-Neuropsin (Mouse) mAb

Code No.　M021-3

Anti-Neuropsin (Mouse) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 25, 2024 in JST）

Size

100 µL (1 mg/mL)

Data

  • Western Blotting

  • Immunoprecipitation
Clonality Monoclonal Clone MabB5
Isotype (Immunized Animal) Rat IgG2a
Applications
WB
1-5 µg/mL  
IP
2 µg/sample  
IC*
reported.  （PMID: 11854276）
IH*
reported.  （PMID: 9620300）
Function*
reported.  （PMID: 27327541）
NT*
reported.  （PMID: 12944500 / 16308352）
Immunogen (Antigen) Recombinant
Reactivity [Gene ID]

Mouse[259277]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Klk8, Kallikrein 8, kallikrein related-peptidase 8
Background Neuropsin is a trypsin-type, extracellular, serine protease that was first cloned from mouse limbic brain as a factor related to neural plasticity. Physiological studies indicated that kindling stimulation induced neuropsin mRNA and its protease activity also increased in limbic areas during kindling and long-term potentiation. Subsequent study indicated that neuropsin mRNA localized not only in the limbic brain, but also in developing organs and adult keratinocytes. Recent immunohistochemical analysis demonstrated that neuropsin localized exclusively in the keratinizing epithelia of the epidermis and various stratified mucous membranes. During development, neuropsin was found in the various epithelia at embryonic days 14.5-15.5, prior to formation of the stratum corneum. Much stronger expression of neuropsin is observed in nude mouse skin and mucous membranes than in normal mice. Those studies suggested that neuropsin is related to differentiation of keratinocytes and the process of keratogenesis.
Citations
  1. Momota Y et al. Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy. Eur J Neurosci. 10, 760-4 (1998)(PMID:9749739)

Western Blotting

  1. Shimizu C et al. Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem. 273, 11189-96 (1998)(PMID:9556608)

Neutralization

  1. Matsumoto-Miyai K et al. NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci. 23, 7727-36 (2003)(PMID:12944500)
  2. Tamura H et al. Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol. 570, 541-51 (2006)(PMID:16308352)

Immunoprecipitation

  1. Shimizu C et al. Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. J Biol Chem. 273, 11189-96 (1998)(PMID:9556608)
  2. Kato K et al. Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain. J Biol Chem. 276, 14562-71 (2001)(PMID:11278732)

Immunocytochemistry

  1. Oka T et al. Role of loop structures of neuropsin in the activity of serine protease and regulated secretion. J Biol Chem. 277, 14724-30 (2002)(PMID:11854276)

Immunohistochemistry

  1. Inoue N et al. Expression of neuropsin in the keratinizing epithelial tissue-immunohistochemical analysis of wild-type and nude mice. J Invest Dermatol. 110, 923-31 (1998)(PMID:9620300)

Function

  1. Herring A et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 12, 1273-1287 (2016)(PMID:27327541)
Product category
Research area
Neuroscience
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Apr 25, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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