Anti-Glutamic Acid Decarboxylase (GAD) mAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Western Blotting
Clonality	Monoclonal	Clone	9A6
Isotype (Immunized Animal)	Mouse IgG1 κ
Applications	WB 1 µg/mL IH 1-10 µg/mL
Immunogen (Antigen)	Recombinant Human full-length GAD65 (1-585 a.a.)
Reactivity [Gene ID]	Human*[2572](PMID: 28789479), Mouse[14417], Rat[24380]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	Gad2, GAD65, Gad-2, GAD(65)
Background	Glutamic acid decarboxylase (GAD) catalyzes formation of γ-Aminobutyric acid (GABA), which is the inhibitory neurotransmitter, and is present in brain as well as several tissues outside the central nervous system. Biological functions of GAD and GABA extend beyond regulation of neurotransmission to include effects on the immune system as well as modulation of cell proliferation, protein synthesis, and metabolism. Two isoforms of GAD, GAD<sub>65</sub> and GAD<sub>67</sub> each derives from a single separate gene, were isolated from human fetal brain lgt11 cDNA library.
Citations	Western Blotting Kuwajima T et al. Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. J Neurosci. 26, 5383-5392 (2006)(PMID:16707790) Immunohistochemistry Kuwajima T et al. Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. J Neurosci. 26, 5383-5392 (2006)(PMID:16707790) Volgin DV et al. Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep. PLoS One 9,e86545 (2014)(PMID:24466145) Becker AB et al. Heart and Nervous System Pathology in Compound Heterozygous Friedreich Ataxia. J Neuropahtol Exp Neurol. 76, 665-675 (2017)(PMID:28789479)
Product category	Research area Neuroscience

The availability is based on the information in Japan at 00:05, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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