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HOME > Product search results > Code No. K0220-3 Anti-MICB (Human) mAb

Code No. K0220-3

Anti-MICB (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Nov 20, 2018 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone BMO1
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
FCM
10 µg/mL (final concentration)  
ELISA
1 µg/mL (for capture antibody)  
Immunogen (Antigen) MICA*01, MICA*04 and MICB*02 transfected P815 cells
Reactivity [Gene ID]

Human[4277]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names MHC class I polypeptide-related sequence B, PERB11.2
Background MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, γδT cells and CD8+ αβT cells. Recognition of MICA and MICB by NKG2D is involved in tumor surveillance, immune responses to viral infections and autoimmune diseases. MICA and MICB are transmembrane glycoproteins that are distantly related to the MIC proteins, and they possess three extra-cellular Ig-like domains. And thus, MICA and MICB are closely related but are functionally indistinguishable. MICA and MICB molecules are highly glycosylated, and are detected as a smear band ranging from 65-75 kDa. It is reported that MICA and MICB are highly expressed in variant tumor cells, whereas normal cells express little. Tumor cells have been shown to shed and release MIC molecules from the cell surface. Therefore determination of soluble MIC (sMIC) levels provides valuable information for cancer staging, and sMIC in serum seems to be an indicator for systemic manifestation of malignancy rather than for local tumor extent.
Related products K0217-3 Anti-MICA (Human) mAb
K0218-3 Anti-MICA/B (Human) mAb
K0219-3 Anti-MICA/B (Human) mAb
Citations

Flow Cytometry

  1. Miyashita T et al. Low-dose valproic acid with low-dose gemcitabine augments MHC class I-related chain A/B expression without inducing the release of soluble MHC class I-related chain A/B. Oncol Lett. 14, 5918-5926 (2017)(PMID:29113227)
Product category
Research area
Immunology
Cancer
Cell surface antigens
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  • The availability is based on the information in Japan at 00:05, Nov 20, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.