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HOME > Product search results > Code No. K0205-3 Anti-Txnip (VDUP1) mAb

Code No. K0205-3

Anti-Txnip (VDUP1) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Dec 13, 2017 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunoprecipitation

Clonality Monoclonal Clone JY2
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
1 µg/mL  
IP
2 µg/200 µL of cell extract from 5x106 cells  
IC*
reported.  (PMID: 27929088
IH*
reported.  (PMID: 19959470 / 23584857
Immunogen (Antigen) Recombinant Human Txnip/VDUP1
Reactivity [Gene ID]

Human[10628], Mouse[56338], Rat*[117514](19258488/23803610/26858253)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names thioredoxin interacting protein, THIF, VDUP1
Background Thioredoxin (TRX)-binding protein (Txnip), also called Vitamin D3 up-regulated protein 1 (VDUP1) is an endogenous inhibitor of TRX. Redox-dependent regulation of Txnip by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of Txnip to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX. It has been reported that Txnip plays important roles in diverse cellular processes, including the regulation of cellular redox balance, apoptosis, proliferation, and differentiation.
Related products K0204-3 Anti-Txnip (VDUP1) mAb
M013-3 Anti-Thioredoxin (Trx-tag) mAb
M063-3 Anti-Thioredoxin (Human) mAb
M075-3 Mouse IgG1 (isotype control)
D168-3 Anti-Importin α1 (Rch1) mAb
Citations
  1. Pang ST et al. Thioredoxin-interacting protein: an oxidative stress-related gene is upregulated by glucose in human prostate carcinoma cells. J Mol Endocrinol. 42, 205-14 (2009)(PMID:19052253)

Western Blotting

  1. Yoshioka J et al. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 101, 1328-38 (2007)(PMID:17916779)
  2. Chen J et al. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 57, 938-44 (2008)(PMID:18171713)
  3. Chen J et al. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. Am J Physiol Endocrinol Metab. 296, E1133-9 (2009)(PMID:19258488)
  4. Patwari P et al. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. J Biol Chem. 284, 24996-5003 (2009)(PMID:19605364)
  5. Saxena G et al. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 285, 3997-4005 (2010)(PMID:19959470)
  6. Kibbe C et al. FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. J Biol Chem. 288, 23194-202 (2013)(PMID:23803610)
  7. Jing G et al. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. J Biol Chem. 289, 11807-15 (2014)(PMID:24627476)
  8. Hong K et al. Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. J Biol Chem. 291, 8428-39 (2016)(PMID:26858253)
  9. Ahn B et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Cin Invest. 126, 3567-79 (2016)(PMID:27500491)
  10. Hulmi JJ et al. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radic  Biol Med. 99, 308-322 (2016)(PMID:27554968)
  11. Du RH et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 9, 178-187 (2016)(PMID:27566281)
  12. Coucha M et al. THigh fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. World J Diabetes. 8, 56-65 (2017)(PMID:28265343)
  13. Morita S et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 25, 863-897.e8. (2017)(PMID:28380378)
  14. Park S et al. Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells. Redox Biol. 13, 470-476 (2017)(PMID:28715732)

Immunocytochemistry

  1. Jung H et al. Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity. Nat Commun. 7, 13674 (2016)(PMID:27929088)

Immunohistochemistry

  1. Saxena G et al. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 285, 3997-4005 (2010)(PMID:19959470)
  2. Hand LE et al. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology 154, 2081-91 (2013)(PMID:23584857)
  3. Morrison JA et al. Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer. Mol Cancer. 13, 62 (2014)(PMID:24645981)
Product category
Research area
Cellular stress
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  • The availability is based on the information in Japan at 01:30, Dec 13, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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