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HOME > Product search results > Code No. K0122-1 Anti-CD160 (Human) mAb

Code No. K0122-1

Anti-CD160 (Human) mAb

Availability (in Japan)

1-9

(In Japan at 00:05,
Nov 15, 2018 in JST)

Size

100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone CL1-R2
Isotype (Immunized Animal) Mouse IgG1
Applications
IP*
reported.  (PMID: 11978774
FCM
1:100 (final concentration)  
Function*
reported.  (PMID: 21959263 / 25179432 / 26071079
Immunogen (Antigen) CD160 transfected Jurkat cells
Reactivity [Gene ID]

Human[11126]

Storage buffer supernatant with preservative (0.1% Proclin 150)
Storage temp. 4°C Conjugate Unlabeled Manufacturer MBL
Alternative names CD160 molecule, NK1, BY55, NK28
Background CD160, also known as BY55 antigen, is a GPI-anchored cell surface receptor found on a small subset of T-effector cells that have cell killing activity. CD160, which has a broad specificity for MHC class Ia and Ib molecules, behaves as a co-receptor upon T cell activation. Similarly, binding of CD160 to HLA-C has been shown to activate cytotoxic function in NK cells. CD160 monoclonal antibody has potential therapeutic use as an anti-inflammatory or tolerance-promoting drug to eliminate self-reactive T-effector cells.
Related products K0016-1 Anti-CD57 (Human) mAb
K0061-3 Anti-CD161 (Human) mAb
K0061-4 Anti-CD161 (Human) mAb-FITC
Citations

Function

  1. Kojima R et al. Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413, 762-72 (2011)(PMID:21959263)
  2. EI-Far M et al. CD160 isoforms and regulation of CD4 and CD8 T-cell responses. J Transl Med. 12, 217 (2014)(PMID:25179432)
  3. Zuo J et al. Increased CD160 expression on circulating natural killer cells in atherogenesis. J Transl Med. 13, 188 (2015)(PMID:26071079)
References
  1. Nikolova M et al. BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression. Int Immunol. 14, 445-51 (2002)(PMID: 11978774
  2. Giustiniani J et al. A soluble form of the MHC class I-specific CD160 receptor is released from human activated NK lymphocytes and inhibits cell-mediated cytotoxicity. J Immunol. 178, 1293-1300 (2007)(PMID: 17237375
Product category
Research area
Immunology
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Nov 15, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.