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HOME > Product search results > Code No. K0046-5 Anti-Integrin α7 (Mouse) mAb-PE

Code No. K0046-5

Anti-Integrin α7 (Mouse) mAb-PE

Availability (in Japan)

10 or more

(In Japan at 01:30,
Dec 17, 2017 in JST)

Size

1 mL (50 tests)

Clonality Monoclonal Clone 3C12
Isotype (Immunized Animal) Mouse IgG1
Applications
FCM
20 µL (Ready for use.)  
Immunogen (Antigen) Mouse myoblasts
Reactivity [Gene ID]

Mouse[16404]

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate PE Manufacturer MBL
Alternative names Itga7, integrin alpha 7, [a]7, alpha7
Background

The integrin family of adhesion molecules participate in important cell-cell and cell-extracellular matrix interactions in a diverse range of biological processes. Integrins are heterodimers consisting of α and β subunits. Both α and β subunits are transmembrane proteins with large extracellular domains (>100 kDa for α subunit and >75 kDa for β subunit) that interact with extracellular matrix proteins and relatively small cytoplasmic domains (50 amino acids or less, except for the β4 subunit) that interact with cytoskeletal proteins. The adhesiveness of integrins is dynamically regulated in response to cytoplasmic signals, termed “inside-out” signaling. It has been reported that, upon ligand binding, integrins regulate many intracellular signaling pathways that involve cytoplasmic alkalization, intracellular Ca2+ fluctuation, inositol lipid metabolism, protein kinase C, MAP kinase and phosphatidyl inositol kinase. Integrin α7 is a specific cellular receptor for the basement membrane protein laminin-1, as well as for the laminin isoforms-2 and -4. The α7 subunit is expressed mainly in skeletal and cardiac muscle and may be involved in differentiation and migration processes during myogenesis. Absence of integrin α7 results in muscular dystrophy is revealed.

Related products K0046-3 Anti-Integrin α7 (Mouse) mAb
K0046-4 Anti-Integrin α7 (Mouse) mAb-FITC
K0047-3 Anti-Integrin α7 (Mouse) mAb
M075-5 Mouse IgG1 (isotype control)-PE
Citations

Flow Cytometry

  1. Majka SM et al. Adipose lineage specification of bone marrow-derived myeloid cells. Adipocyte 1, 215-29 (2012)(PMID:23700536)
  2. Xynos A et al. Overexpression of facioscapulohumeral muscular dystrophy region gene 1 causes primary defects in myogenic stem cells. J Cell Sci. 126, 2236-45 (2013)(PMID:23525014)
Product category
Research area
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Dec 17, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.