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HOME > Product search results > Code No. D364-3 Anti-TLR3 (CD283) (Human) mAb

Code No. D364-3

Anti-TLR3 (CD283) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Dec 14, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

  • Immunocytochemistry

Clonality Monoclonal Clone TLR3.7
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
IP*
reported.  (PMID: 12054664 / 12960343 / 15226270
FCM
5 μg/mL  
IC
5 μg/mL  
IH*
reported.  (PMID: 21129170 / 22023039
Function*
reported.  (PMID: 12054664
Immunogen (Antigen) Ba/F3 cells stably expressing human Flag-tagged TLR3
Reactivity [Gene ID]

Human[7098]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Toll-like receptor 3
Background Human TLR3 consists of an extracellular domain containing 23 leucine rich repeats and N- and C-terminal flanking regions, the transmembrane domain, and the intracellular Toll-IL-1 receptor homology domain. It possesses 15 putative carbohydrate-binding motifs in the extracellular domain. Human TLR3 is expressed in myeloid DCs, macrophages, fibroblasts and a variety of epithelial cells. TLR3 localizes on endosomes in myeloid DCs and both on the cell surface and endosomes in fibroblasts, macrophages and some of epithelial cell lines. TLR3 recognizes double-stranded RNA including poly(I:C), induces the activation of NF-κB, AP-1 and IRF3 through the TICAM-1-dependent pathway, resulting in the production of IFN-γ and proinflammatory cytokines. TLR3.7 inhibits poly(I:C)-induced IFN-γ production by human fibroblasts naturally expressing TLR3 on their surface.
Related products K0210-3 Anti-TLR1 (CD281) (Human) mAb
D077-3 Anti-TLR4 (CD284) (Human) mAb
PD047 Anti-TLR8 (CD288) (Human) pAb
K0213-3 Anti-TLR9 (CD289) mAb
References
  1. Matsumoto M et al. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293, 1364-9 (2002)(PMID: 12054664
  2. Matsumoto M et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol. 171, 3154-62 (2003)(PMID: 12960343
  3. Funami K et al. The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol. 16, 1143-54 (2004)(PMID: 15226270
  4. Takada E et al. C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission. Mol Immunol. 44, 3633-40 (2007)(PMID: 17521732
  5. Matsumoto M, Seya T. TLR3: interferon induction by double-stranded RNA including poly(I:C). Adv Drug Deliv Rev. 60, 805-12 (2008)(PMID: 18262679
  6. González-Reyes S et al. Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer 10, 665 (2010)(PMID: 21129170
  7. Hashad DI et al. Toll like receptor 3 expression as a novel predictor of response to treatment in chronic hepatitis C virus patients. Scand J Clin Lab Invest. 71, 641-6 (2011)(PMID: 22023039
Product category
Research area
Immunology
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Dec 14, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.