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HOME > Product search results > Code No. D271-4 Anti-CD8 (Mouse) mAb-FITC

Code No. D271-4

Anti-CD8 (Mouse) mAb-FITC

Availability (in Japan)

10 or more

(In Japan at 00:05,
Sep 20, 2018 in JST)

Size

1 mL (100 tests)

Data
  • Flow Cytometry

Clonality Monoclonal Clone KT15
Isotype (Immunized Animal) Rat IgG2aλ
Applications
FCM
10 µL (Ready for use.)  
Immunogen (Antigen) T cell clone C6, H-2Kk restricted H-Y antigen specific CTL
Reactivity [Gene ID]

Mouse[12525]

Storage buffer PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C Conjugate FITC Manufacturer MBL
Background The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two α chains, or a heterodimer composed of one α and one β chain. Both α and β chains share significant homology to immunoglobulin variable light chains. CD8 α chains bind to class-I MHC molecules α3 domains. CD8 identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.This monoclonal antibody KT15 reacts with a non-polymorphic epitope on the mouse CD8 α chain (mouse Ly2.1 and Ly2.2 cells).
Related products D271-A64 Anti-CD8 (Mouse) mAb-Alexa Fluor® 647
D341-4 Anti-CD4 (Mouse) mAb-FITC
M090-4 Rat IgG2b (isotype control)-FITC
D271-5 Anti-CD8 (Mouse) mAb-PE
M081-4 Rat IgG2a (isotype control)-FITC
D056-3 Anti-CD43 (Human) mAb
Citations

Flow Cytometry

  1. Asano J et al. Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J. Immunol. 184, 736-45 (2010)(PMID:20008287)
  2. Kayamuro H et al. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol. 84, 12703-12 (2010)(PMID:20881038)
  3. Nobuoka D et al. Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunotherapy. Cancer Immunol Immunother. 62, 639-52 (2013)(PMID:23143746)
  4. Ohyagi H et al. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity 39, 584-98 (2013)(PMID:24035363)
  5. Sawada Y et al. Programmed death-1 blockade enhances the antitumor effects of peptide vaccine-induced peptide-specific cytotoxic T lymphocytes. Int J Oncol. 46, 28-36 (2015)(PMID:25354479)
  6. Toyota H et al. Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo. Oncol Rep. 33, 292-6 (2015)(PMID:25394516)
  7. Kamimura D et al. Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells. Int Immunol. 28, 117-26 (2016)(PMID:26489882)
  8. Uematsu T et al. Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity. Sci Rep. 5, 17577 (2015)(PMID:26627732)
  9. Matsueda S et al. Antitumor activity of antibody against cytotoxic T lymphocyte epitope peptide of lymphocyte-specific protein tyrosine kinase. Cancer Sci. 109, 611-617 (2018)(PMID:29388341)
  10. Ouchi Y et al. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing. Int Immunol. 30, 141-154 (2018)(PMID:29617862)
  11. Kim JW et al. A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model. Mol Ther Oncolytics. 5, 97-104 (2017)(PMID:28573184)
Product category
Research area
Immunology
Cell surface antigens
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  • The availability is based on the information in Japan at 00:05, Sep 20, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.