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HOME > Product search results > Code No. D270-3 Anti-Musashi-1 (Msi1) mAb

Code No. D270-3

Anti-Musashi-1 (Msi1) mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Oct 20, 2018 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunohistochemistry

Clonality Monoclonal Clone 14H1
Isotype (Immunized Animal) Rat IgG2aκ
Applications
WB
1 µg/mL  
IC*
  (PMID: 27799368
IH
2 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Recombinant Mouse Musashi-1 (190-362 a.a.)
Reactivity [Gene ID]

Human[4440], Mouse[17690], Rat[259272]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Msi1h, Musashi1
Background Musashi-1 (Msi1) is a highly conserved RNA binding protein with important functions in stem cell maintenance, nervous system development and tumorigenesis. Musashi-1 inhibit translation initiation of its target mRNA, m-Numb, by competing with eIF4G for Poly A Binding Protein. Musashi-1 is mainly expressed in stem and progenitor cells from different tissues in mammals, and a decrease occurs as cells commit to lineage differentiation. Recently, expression of Musashi-1 in mature photoreceptors and retinal pigment epithelium cells was found and its expression in those cells is absolutely necessary for survival of photoreceptors.
Related products RN010P Anti-MSI1 (Musashi1) pAb
D270-6 Anti-Musashi-1 (Msi1) (Mouse) mAb-Biotin
Citations

Immunocytochemistry

  1. Yousefi M et al. Msi RNA-binding proteins control reserve intestinal stem cell quiescence. J Cell Biol. 215, 401-413 (2016)(PMID:27799368)

Immunohistochemistry

  1. Takeda H et al. Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells. Genesis 51, 128-34 (2013)(PMID:23132814)
  2. Katz Y et al. Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state. Elife 3, e03915 (2014)(PMID:25380226)
  3. Yousefi M et al. Msi RNA-binding proteins control reserve intestinal stem cell quiescence. J Cell Biol. 215, 401-413 (2016)(PMID:27799368)
References
  1. Kaneko Y et al. Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Dev Neurosci. 22, 139-53 (2000)(PMID: 10657706
Product category
Research area
Stem cell research
Cancer
Neuroscience
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  • The availability is based on the information in Japan at 00:05, Oct 20, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.