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HOME > Product search results > Code No. D230-3 Anti-CD274 (PD-L1) (Human) mAb

Code No. D230-3

Anti-CD274 (PD-L1) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Dec 14, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 27A2
Isotype (Immunized Animal) Mouse IgG2b
Applications
FCM
10 µg/mL (final concentration)  
IH
10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Recombinant Human PD-L1 extracellular domain
Reactivity [Gene ID]

Human[29126]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names B7H1
Background Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although <em>in vitro</em> study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-&gamma; GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable.
Related products D230-5 Anti-CD274 (PD-L1) (Human) mAb-PE
D092-6 Anti-CD274 (PD-L1) (Human) mAb-Biotin
D092-3M2 Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)
D133-3M2 Anti-CD279 (PD-1) (Human) mAb (Functional Grade)
D092-3 Anti-CD274 (PD-L1) (Human) mAb
D231-3 Anti-CD273 (PD-L2) (Mouse) mAb
D132-3 Anti-CD279 (PD-1) (Human) mAb
D132-4 Anti-CD279 (PD-1) (Human) mAb-FITC
D132-5 Anti-CD279 (PD-1) (Human) mAb-PE
D133-5 Anti-CD279 (PD-1) (Human) mAb-PE
Citations

Immunohistochemistry

  1. Hamanishi J et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. PNAS. 104, 3360-5 (2007)(PMID:1736065)
  2. Schuchmann M et al. The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation. Am J Transplant. 8, 2434-44 (2008)(PMID:18925909)
  3. Hino R et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 116, 1757-66 (2010)(PMID:20143437)
  4. Gadiot J et al. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 117, 2192-201 (2011)(PMID:21523733)
  5. Droeser RA et al. Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer 49, 2233-42 (2013)(PMID:23478000)
  6. Hamanishi J et al. Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. J Clin Oncol. 33, 4015-22 (2015)(PMID:26351349)
Product category
Research area
Immunology
Cancer
Apoptosis
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Dec 14, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.