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HOME > Product search results > Code No. D227-3 Anti-PA28α mAb

Code No. D227-3

Anti-PA28α mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Nov 22, 2018 in JST)

Size

100 µg/100 µL

Data
  • Immunoprecipitation

Clonality Monoclonal Clone 1G11
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 µg/mL  
IP
5 µg/200 µL of cell extract from 5x106 cells  
IH
1 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Recombinant Mouse full length PA28α
Reactivity [Gene ID]

Human[5720], Mouse[19186], Rat[29630]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names PSME1, proteasome activator subunit 1, PA28A, IFI5111, REGalpha, HEL-S-129m
Background PA28, also called 11S regulator, was identified as a proteasome activator that strongly increases the maximal velocity of the hydrolytic reaction and decreases the concentration of substrate required for cleavage by purified 20S proteasomes. It is known that major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. PA28 also plays an important role in the processing of MHC class I ligands. However, isolated PA28 does not perform enzymatic activity by itself. PA28 is composed of two homologous subunits, PA28α (30 kDa) and PA28β. These two subunits assemble into a heterohexamer (α3β3) or a heteroheptomer (α3β4 or mixture of α3β4 and α4β3). The PA28 complex is expressed constitutively in antigen presenting cells, its expression is upregulated by IFN-γ. It appears to be involved in the presentation of endogenous antigen by MHC class I molecules.
Related products PD003 Anti-PA28γ pAb
M075-3 Mouse IgG1 (isotype control)
Product category
Research area
Ubiquitin proteasome
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  • The availability is based on the information in Japan at 00:05, Nov 22, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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