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HOME > Product search results > Code No. D226-3 Anti-HLA class I (HLA-A,B,C) (Human) mAb

Code No. D226-3

Anti-HLA class I (HLA-A,B,C) (Human) mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Sep 20, 2018 in JST)


100 µg/100 µL

  • Western Blotting

Clonality Monoclonal Clone EMR8-5
Isotype (Immunized Animal) Mouse IgG1
1 µg/mL  
10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen (Antigen) Recombinant HLA-A*2402 extracellular domain
Reactivity [Gene ID]

Human[HLA-A 3105; HLA-B 3106; HLA-C 3107]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names major histocompatibility complex, class I, HLA-A, HLAA/HLA-B, AS, HLAB, SPDA1/HLC-C, D6S204, PSORS1, HLA-JY3
Background Human major histocompatibility complex (MHC) class I antigen-epitope peptide complex associated with β2-microglobulin are expressed by all human nucleated cells. It plays an important role in cell-mediated immune responses. Abnormalities in MHC class I antigen surface expression are frequently found in malignancies and infectious diseases. They are often associated with reduced recognition by MHC class I antigen-restricted, tumor or virus-associated antigen-specific cytotoxic T lymphocytes and disease progression.
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Western Blotting

  1. Li F et al. Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase-dependent manner. Hum Immunol. 72, 1150-9 (2011)(PMID:22001078)


  1. Rasku MA et al. Transient T cell depletion causes regression of melanoma metastases. J Transl. Med. 6, 12 (2008)(PMID:18334033)
  2. Halama N et al. Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines. Clin Cancer Res. 17, 678-89 (2011)(PMID:21325295)
  3. del Campo AB et al. Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma. Int J. Cancer 134, 102-13 (2014)(PMID:23784959)
  4. Fujii H et al. CD8+ tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma. Int J Cancer 134, 2393-402 (2014)(PMID:24243586)
  5. Wick DA et al. Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res. 20, 1125-34 (2014)(PMID:24323902)
  6. Umemoto Y et al. Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy. J Gasteroenterol. 50, 65-75 (2015)(PMID:24509608)
Product category
Research area
Cell surface antigens

  • The availability is based on the information in Japan at 00:05, Sep 20, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.