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HOME > Product search results > Code No. D225-3 Anti-LYVE-1 (Mouse) mAb

Code No. D225-3

Anti-LYVE-1 (Mouse) mAb

Availability (in Japan)

1-9

(In Japan at 01:30,
Jun 26, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

  • Immunohistochemistry

Clonality Monoclonal Clone ALY7
Isotype (Immunized Animal) Rat IgG1 κ
Applications
FCM
5 µg/mL (final concentration)  
IH
10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
IF*
reported.  (PMID: 19759906 / 21666710 / 22200616
Immunogen (Antigen) Recombinant Mouse LYVE-1 extracellular domain (1-228 a.a.)
Reactivity [Gene ID]

Mouse[114332]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Xlkd1, Lyve1, Crsbp-1
Background Hyaluronan (HA) is a high molecular weight polymer composed of alternating glucuronic acid and N-acetylglucosamine. HA is involved in homeostasis, development, and tissue remodeling. A major receptor for HA is designated as LYVE-1 (Lymphatic vessel endothelial hyaluronan receptor-1). LYVE-1 is a ~35 kDa integral membrane protein which is down-ewgulated in human liver cancer and cirrhosis. LYVE-1 localizes on the luminal face of the lymph wall, but is absent from blood vessels. Thus, anti-LYVE-1 antibody is a powerful tool for the identification of lymph vessels and for studies of lymphangiogenesis. LYVE-1 antibodies have been used successfully to distinguish lymphatic invasion by malignant tumor cells from blood vessel invasion.
Related products D225-5 Anti-LYVE-1 (Mouse) mAb-PE
D296-3 Anti-Lyve-1 (Mouse) mAb
Citations

Immunofluorescence

  1. Zumsteg A et al. Myeloid cells contribute to tumor lymphangiogenesis. PLoS One 4, e7067 (2009)(PMID:19759906)
  2. Min Y et al. C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α. Oncogene 30, 4901-9 (2011)(PMID:21666710)
  3. Kajiya K et al. Promotion of lymphatic integrity by angiopoietin-1/Tie2 signaling during inflammation. Am J Pathol. 180, 1273-82 (2012)(PMID:22200616)
  4. Li W, Mukouyama YS. Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature. Dev Dyn. 242, 976-88 (2013)(PMID:23649798)
  5. Tan KS et al. Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos. Biol Open. 4, 596-607 (2015)(PMID:25887124)
Product category
Research area
Immunology
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Jun 26, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.