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HOME > Product search results > Code No. D204-3 Anti-CD52 (CAMPATH-1) (Mouse) mAb

Code No. D204-3

Anti-CD52 (CAMPATH-1) (Mouse) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Aug 20, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone BTG-2G
Isotype (Immunized Animal) Rat IgG2a
Applications
IP
20 µg/mL of cell extract from 5x106 cells  
FCM
10 µg/mL (final concentration)  
Immunogen (Antigen) mouse IL-2R alpha-transgenic mouse splenocytes
Reactivity [Gene ID]

Mouse[23833]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Background CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages.  The function of CD52 is unknown.  However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity.  Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis.  The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry.
Related products D204-5 Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE
D204-4 Anti-CD52 (CAMPATH-1) (Mouse) mAb-FITC
Citations
  1. Sakuragi J et al. A rapid recombination assay of HIV-1 using murine CD52 as a novel biomarker. Microbes Infect. 10, 396-404 (2008)(PMID:18407776)
Product category
Research area
Immunology
Cancer
Cell surface antigens
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  • The availability is based on the information in Japan at 01:30, Aug 20, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.