Availability (in Japan)
1-9
(In Japan at 23:00,
Apr 26, 2018 in JST)
Size
100 µg/100 µL
Data | |||||
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Clonality | Monoclonal | Clone | 1D6 | ||
Isotype (Immunized Animal) | Mouse IgG1 | ||||
Applications |
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Immunogen (Antigen) | Human CD257/BAFF/BLyS transfectant | ||||
Reactivity [Gene ID] | Human[10673] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | TNFSF13B, DTL, TALL1, THANK, ZTNF4, TALL-1, TNFSF20 | ||||
Background | CD257/BAFF (B cell-activating factor belonging to the TNF family) is a membrane protein expressed by dendritic cells, monocytes, macrophages, follicular dendritic cells, activated T cells, activated neutrophiles, and malignant B cells. CD257/BAFF, also known as BLyS (B lymphocyte stimulator), is a potent B cell growth factor. Proteolytic cleavage can result in the release of a soluble trimeric BAFF which binds to the BAFF receptor (BAFF-R/CD268/BR3), BCMA and TACI. The release of soluble BAFF is regulated by IFN-γ and to a lesser extent IL-10. BAFF protects B cells from apoptosis and increases the expression of anti-apoptotic proteins Bcl-2 and Bcl-xL. | ||||
Related products | D200-4 Anti-CD257 (BAFF/BLyS) (Human) mAb-FITC D201-3 Anti-CD268 (BAFF-R/BR3) (Human) mAb D201-4 Anti-CD268 (BAFF-R/BR3) (Human) mAb-FITC |
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Citations |
Western Blotting
Flow Cytometry
Immunohistochemistry
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Product category |