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HOME > Product search results > Code No. D200-3 Anti-CD257 (BAFF/BLyS) (Human) mAb

Code No.　D200-3

Anti-CD257 (BAFF/BLyS) (Human) mAb

Availability (in Japan)

1-9

（In Japan at 23:00,
Apr 26, 2018 in JST）

Size

100 µg/100 µL

Data

  • Flow Cytometry
Clonality Monoclonal Clone 1D6
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
1 μg/mL  
FCM
5 μg/mL (final concentration)  
IC
5 μg/mL (Heat treatment is necessary for paraffin embedded sections.)  
IH*
reported.  （PMID: 14630796）
Immunogen (Antigen) Human CD257/BAFF/BLyS transfectant
Reactivity [Gene ID]

Human[10673]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names TNFSF13B, DTL, TALL1, THANK, ZTNF4, TALL-1, TNFSF20
Background CD257/BAFF (B cell-activating factor belonging to the TNF family) is a membrane protein expressed by dendritic cells, monocytes, macrophages, follicular dendritic cells, activated T cells, activated neutrophiles, and malignant B cells. CD257/BAFF, also known as BLyS (B lymphocyte stimulator), is a potent B cell growth factor. Proteolytic cleavage can result in the release of a soluble trimeric BAFF which binds to the BAFF receptor (BAFF-R/CD268/BR3), BCMA and TACI. The release of soluble BAFF is regulated by IFN-γ and to a lesser extent IL-10. BAFF protects B cells from apoptosis and increases the expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.
Related products D200-4 Anti-CD257 (BAFF/BLyS) (Human) mAb-FITC
D201-3 Anti-CD268 (BAFF-R/BR3) (Human) mAb
D201-4 Anti-CD268 (BAFF-R/BR3) (Human) mAb-FITC
Citations

Western Blotting

  1. Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796)

Flow Cytometry

  1. Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796)

Immunohistochemistry

  1. Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796)
Product category
Research area
Apoptosis
Cell surface antigens
Cytokine & Growth Factors
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 23:00, Apr 26, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.