Anti-CD257 (BAFF/BLyS) (Human) mAb

Availability (in Japan)

1-9

（In Japan at 00:05,
Nov 20, 2018 in JST）

Size

100 µg/100 µL

Citations

Data Sheet

SDS

Data	Flow Cytometry
Clonality	Monoclonal	Clone	1D6
Isotype (Immunized Animal)	Mouse IgG1
Applications	WB 1 μg/mL FCM 5 μg/mL (final concentration) IC 5 μg/mL (Heat treatment is necessary for paraffin embedded sections.) IH* reported. （PMID: 14630796）
Immunogen (Antigen)	Human CD257/BAFF/BLyS transfectant
Reactivity [Gene ID]	Human[10673]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	－２０°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	TNFSF13B, DTL, TALL1, THANK, ZTNF4, TALL-1, TNFSF20
Background	CD257/BAFF (B cell-activating factor belonging to the TNF family) is a membrane protein expressed by dendritic cells, monocytes, macrophages, follicular dendritic cells, activated T cells, activated neutrophiles, and malignant B cells. CD257/BAFF, also known as BLyS (B lymphocyte stimulator), is a potent B cell growth factor. Proteolytic cleavage can result in the release of a soluble trimeric BAFF which binds to the BAFF receptor (BAFF-R/CD268/BR3), BCMA and TACI. The release of soluble BAFF is regulated by IFN-γ and to a lesser extent IL-10. BAFF protects B cells from apoptosis and increases the expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.
Related products	D200-4 Anti-CD257 (BAFF/BLyS) (Human) mAb-FITC D201-3 Anti-CD268 (BAFF-R/BR3) (Human) mAb D201-4 Anti-CD268 (BAFF-R/BR3) (Human) mAb-FITC
Citations	Western Blotting Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796) Flow Cytometry Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796) Immunohistochemistry Hase H et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103, 2257-65 (2004)(PMID:14630796)
Product category	Research area Apoptosis Cell surface antigens Cytokine & Growth Factors

The availability is based on the information in Japan at 00:05, Nov 20, 2018 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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