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HOME > Product search results > Code No. D187-5 Anti-Dlk (Pref-1) mAb-PE

Code No. D187-5

Anti-Dlk (Pref-1) mAb-PE

Availability (in Japan)

10 or more

(In Japan at 00:05,
Dec 14, 2018 in JST)

Size

1 mL (50 tests)

Data
  • Flow Cytometry

Clonality Monoclonal Clone 24-11
Isotype (Immunized Animal) Rat IgG1
Applications
FCM
20 µL (Ready for use.)  
Immunogen (Antigen) Pref-1-Fc
Reactivity [Gene ID]

Mouse[13386]

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate PE Manufacturer MBL
Alternative names Dlk1, delta-like 1 homolog (Drosophila), FA1, ZOG, pG2, DlkI, Peg9, SCP1, DLK-1, Ly107, pref-1, AW742678
Background Delta like protein (Dlk), also known as Preadipocyte factor-1 (Pref-1) or zona glomerulosa-specific factor (ZOG), is an EGF-like transmembrane protein expressed preadipocytes but not in mature adipocytes.  It is highly expressed in fetal liver, the adrenal gland, and placenta, as well as some neuroendocrine tumors and small cell lung carcinomas, where it plays a role in differentiation and proliferation. Dlk positively and negatively regulates adipocyte differentiation via at least four major variants (45-60 kDa) of Dlk generated by alternatively splicing.  Constitutive expression of Dlk inhibits adipogenesis, but insulin or insulin like growth factor-1 (IGF-1) can circumvent this inhibition. Regulated processing of Dlk releases a 50 kDa soluble form that was previously characterized as Fetal Antigen-1, a protein involved in pancreatic island cell differentiation.
Related products D187-3 Anti-Dlk (Pref-1) mAb
D187-4 Anti-Dlk (Pref-1) mAb-FITC
D118-3 Anti-Liv2 (Mouse) mAb
Citations

Flow Cytometry

  1. Takeshita et al. Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL. J Biol Chem. 289, 16699-16710 (2014)(PMID:24753250)
Product category
Research area
Stem cell research
Cancer
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  • The availability is based on the information in Japan at 00:05, Dec 14, 2018 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.