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HOME > Product search results > Code No. D146-3 Anti-Nectin-1 (Mouse) mAb

Code No. D146-3

Anti-Nectin-1 (Mouse) mAb

Availability (in Japan)

10 or more

(In Japan at 01:30,
Nov 20, 2017 in JST)

Size

100 µg/100 µL

Data
  • Immunocytochemistry

Clonality Monoclonal Clone 48-12
Isotype (Immunized Animal) Rat IgG2a
Applications
WB*
  (PMID: 24587018
IC
20 μg/mL  
IH*
  (PMID: 24587018 / 26663531
Immunogen (Antigen) Mouse Nectin1 extracellular region (28-345 a.a.)-IgG-Fc fusion protein
Reactivity [Gene ID]

Mouse[58235]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names CD111, PRR, HIgR, HveC, PRR1, Pvrl1
Background Nectins originally identified as poliovirus receptor-related protein (PRR) are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules. Nectins comprise a family of four members: nectin-1 (CD111/PRR1), nectin-2 (CD112/PRR2), nectin-3 (CD113/PRR3) and nectin-4 (PRR4). Nectin-2 and -3 are ubiquitously expressed whereas nectin-1 is abundantly expressed in brain, and nectin-4 is in placenta. Nectins colocalized with afadin, which an actin-filament binding protein to associated with the actin cytoskeleton. Nectins play important roles in diverse cell-cell junctions.
Related products D083-3 Anti-CD112 (Nectin-2) (Mouse) mAb
D084-3 Anti-CD113 (Nectin-3) (Mouse) mAb
K0224-3 Anti-Nectin-3 (CD113) (Human) mAb
K0224-A48 Anti-Nectin-3 (CD113) (Human) mAb-Alexa Fluor® 488
D175-3 Anti-CD112 (Human) mAb
D175-4 Anti-CD112 (Human) mAb-FITC
Citations

Western Blotting

  1. Toyoshima D et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS One 9, e89763 (2014)(PMID:24587018)

Immunocytochemistry

  1. Togashi H et al. Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery. J Cell Biol. 174, 141-51 (2006)(PMID:16801389)
  2. Ishiuchi T, Takeichi M. Nectins localize Willin to cell-cell junctions. Genes Cells. 17, 387-97 (2012)(PMID:22512338)

Immunohistochemistry

  1. Toyoshima D et al. Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons. PLoS One 9, e89763 (2014)(PMID:24587018)
  2. Geng X et al. Regulatory role of the cell adhesion molecule nectin‐1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus. Genes Cells. 21, 88-98 (2016)(PMID:26663531)
Product category
Research area
Neuroscience
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Nov 20, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.