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HOME > Product search results > Code No. D133-3M2 Anti-CD279 (PD-1) (Human) mAb (Functional Grade)

Code No. D133-3M2

Anti-CD279 (PD-1) (Human) mAb (Functional Grade)

Availability (in Japan)

10 or more

(In Japan at 01:30,
May 28, 2017 in JST)

Size

100 µg/100 µL

Data
  • Flow Cytometry

  • Flow Cytometry

Clonality Monoclonal Clone J105
Isotype (Immunized Animal) Mouse IgG1
Applications
FCM
5 µg/mL  
Immunogen (Antigen) Fc-fusion human PD-1 protein
Reactivity [Gene ID]

Human[5133]

Storage buffer 1 mg/mL in PBS. Azide free, 0.22 μm sterile-filtered
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names PDCD1, programmed cell death 1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Background Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
Related products M075-3M2 Mouse IgG1 (isotype control) (Functional Grade)
D133-3 Anti-CD279 (PD-1) (Human) mAb
D133-5 Anti-CD279 (PD-1) (Human) mAb-PE
D132-3 Anti-CD279 (PD-1) (Human) mAb
D132-4 Anti-CD279 (PD-1) (Human) mAb-FITC
D132-5 Anti-CD279 (PD-1) (Human) mAb-PE
D092-3 Anti-CD274 (PD-L1) (Human) mAb
D092-6 Anti-CD274 (PD-L1) (Human) mAb-Biotin
D230-3 Anti-CD274 (PD-L1) (Human) mAb
D230-5 Anti-CD274 (PD-L1) (Human) mAb-PE
D092-3M2 Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)
References
  1. Iwai Y et al. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 83, 215-20 (2002)(PMID: 12095712
  2. Kanai T et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 171, 4156-63 (2003)(PMID: 14530338
Product category
Research area
Immunology
Cancer
Apoptosis
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, May 28, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.