Anti-CD279 (PD-1) (Human) mAb

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 16, 2024 in JST）

Size

100 µL (1 mg/mL)

Data	Flow Cytometry
Clonality	Monoclonal	Clone	J105
Isotype (Immunized Animal)	Mouse IgG1
Applications	FCM 5 µg/mL (final concentration)
Immunogen (Antigen)	Fc-fusion human PD-1 protein
Reactivity [Gene ID]	Human[5133]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	PDCD1, programmed cell death 1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Background	Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
Related products	D132-3 Anti-CD279 (PD-1) (Human) mAb D132-4 Anti-CD279 (PD-1) (Human) mAb-FITC D132-5 Anti-CD279 (PD-1) (Human) mAb-PE D133-5 Anti-CD279 (PD-1) (Human) mAb-PE D133-3M2 Anti-CD279 (PD-1) (Human) mAb (Functional Grade)
Product category	Research area Apoptosis

The availability is based on the information in Japan at 00:05, Apr 16, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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