Anti-Phospho-STAT3 (Tyr708) mAb

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 19, 2024 in JST）

Size

100 µL (1 mg/mL)

This antibody reacts with human and mouse STAT3 phosphorylated at Tyr705, and zebrafish STAT3 phosphorylated at Tyr708.

Data	Western Blotting
Clonality	Monoclonal	Clone	PS3/1
Isotype (Immunized Animal)	Mouse IgG1
Applications	WB 1 µg/mL
Immunogen (Antigen)	12 peptide including phospho-Tyr708 of Zebrafish STAT3 (CVTQPpYLKTKFI) (703-714 a.a.)
Reactivity [Gene ID]	Human[6774], Mouse[20848]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	APRF, HIES
Background	STAT (Signal Transducers and Activators of Transcription) proteins play important roles in development, cell differentiation and cell cycle control. STAT3 is an ~85 kDa protein involved in the signaling pathways of many cytokines and growth factors, including G-CSF and IL-6, where it functions as a negative regulator of transcription. STAT3 is also constitutively activated in a number of human tumors and it possesses anti-apoptotic activity and oncogenic potential. STAT3 may also regulate apoptosis by inhibiting NF-κB. Activation of STAT3 by tyrosine phosphorylation results in dimerization, nuclear translocation and DNA binding.
Citations	Western Blotting Chen C et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia. Cell Death Dis. 11, 135 (2020)(PMID:32075953)
Product category	Research area Cancer Signal transduction

The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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