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HOME > Product search results > Code No. D123-4 Anti-CD184 (CXCR4) mAb-FITC

Code No. D123-4

Anti-CD184 (CXCR4) mAb-FITC

Availability (in Japan)

10 or more

(In Japan at 01:30,
Jun 29, 2017 in JST)

Size

50 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone A145
Isotype (Immunized Animal) Rat IgG1
Applications
FCM
10-20 μg/mL (final concentration)  
Immunogen (Antigen) CXCR4 transfected Cos-1 cells
Reactivity [Gene ID]

Human[7852]

Storage buffer 500 µg/mL in PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate FITC Manufacturer MBL
Alternative names FB22, HM89, LAP3, LCR1, LESTR, NPY3R, WHIM, D2S201E
Background CXCR4/CD184/LESTR/fusin/NPY3R is a G protein-coupled receptor for the CXC chemokine SDF-1. Binding of SDF-1 induces CXCR4 phosphorylation by Ser/Thr kinases, leading to CXCR4 internalization via clathrin-coated pits. CXCR4 functions include co-stimulation in pre-B cell proliferation, induction of apoptosis, and HIV entry, since CXCR4 is one of the 2 major HIV/SIV co-receptors. Early infection with HIV-1 is dominated by CCR5-tropic (R5) viruses. The evolution of CXCR4-tropic (X4) viruses occurs later in the infection and is associated with rapid disease progression. CXCR4 mediates chemotaxis in mature and progenitor blood cells and is essential for B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. Although ubiquitously expressed in blood and tissue cells, its role in blood and tissue homeostasis is not fully understood. CXCR4 is predominantly stored intracellularly, and may contribute to the inefficiency in transmission and propagation of X4-tropic viruses.
Related products D123-3 Anti-CD184 (CXCR4) mAb
D070-5 Anti-CX3CR1 (Human) mAb-PE
Citations

Flow Cytometry

  1. Cesano A et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts.Cytometry B Clin Cytom. 82, 158-72
    (2012)(PMID:22334473)
References
  1. Cesano A et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts. Cytometry B Clin Cytom. 82, 158-72 (2012) (PMID:22334473)
Product category
Research area
Cell surface antigens
Cytokine & Growth Factors
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Jun 29, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.