Availability (in Japan)
1-9
(In Japan at 23:00,
Apr 24, 2018 in JST)
Size
1 mL (50 tests)
Clonality | Monoclonal | Clone | HTA125 | ||
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Isotype (Immunized Animal) | Mouse IgG2a | ||||
Applications |
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Immunogen (Antigen) | human TLR4 transfected cells | ||||
Reactivity [Gene ID] | Human |
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Storage buffer | 80 µg/mL IgG inPBS/1% BSA/0.09% NaN3 | ||||
Storage temp. | 4°C | Conjugate | FITC | Manufacturer | MBL |
Background | Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defenses against bacteria or fungi. Toll-like receptor 4 (TLR4/CD284) is a member of TLR family, which is human homologue of Toll protein. It has extracellular LRR and an intracellular signaling domain, which is similar to the type I IL-1 receptor. TLR4 is expressed in subpopulations of cells including myeloid cells, B cells, monocytes, and endothelial cells. Recent studies have suggested that TLR4 might act as a receptor for lipopolysaccharide (LPS). TLR4 alone is not capable of sensing and signaling the presence of LPS, but another molecule MD-2, which is physically associated with TLR4, is required for LPS recognition through TLR4. |
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Related products | D077-3 Anti-TLR4 (CD284) (Human) mAb D077-5 Anti-TLR4 (CD284) (Human) mAb-PE D205-3 Anti-TLR4 (CD284) (Mouse) mAb D205-4 Anti-TLR4 (CD284) (Mouse) mAb-FITC PD047 Anti-TLR8 (CD288) (Human) pAb K0212-3 Anti-TLR2 (CD282) mAb K0213-3 Anti-TLR9 (CD289) mAb |
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