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HOME > Product search results > Code No. D070-5 Anti-CX3CR1 (Human) mAb-PE

Code No. D070-5

Anti-CX3CR1 (Human) mAb-PE

Availability (in Japan)

10 or more

(In Japan at 01:30,
Jun 29, 2017 in JST)

Size

1 mL (50 tests)

Data
  • Flow Cytometry

Clonality Monoclonal Clone 2A9-1
Isotype (Immunized Animal) Rat IgG2bκ
Applications
FCM
20 µL (Ready for use.)  
Immunogen (Antigen) Human CX3CR1 expressing non-mammalian cells
Reactivity [Gene ID]

Human[1524]

Storage buffer PBS/1% BSA/0.09% NaN3
Storage temp. 4°C Conjugate PE Manufacturer MBL
Alternative names chemokine (C-X3-C motif) receptor 1, V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1
Background There are several subfamilies in the chemokine superfamily. In addition to CXC, CC and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes. CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor family, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion.
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D123-3 Anti-CD184 (CXCR4) mAb
D123-4 Anti-CD184 (CXCR4) mAb-FITC
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Citations
  1. Darbandi-Tehrani K et al. Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays. FASEB J. 24, 4585-98 (2010)(PMID:20667981)
  1. van de Berge PJ et al. Cytomegalovirus-induced effector T cells cause endothelial cell damage. Clin. Vaccine Immunol. 19, 772-9 (2012)(PMID:22398244)
  1. de Niet E et al. Restoration of T cell function in chronic hepatitis B patients upon treatment with interferon based combination therapy. J Hepatol. 64, 539-46 (2016)(PMID:26505119)

Flow Cytometry

  1. Makishima H et al. Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease. Intern Med. 47, 295-8 (2008)(PMID:18277033)
  2. Pachot A et al. Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression. J Immunol. 180, 6421-9 (2008)(PMID:18424766)
  3. Tallone T et al. Heterogeneity of human monocytes: an optimized four-color flow cytometry protocol for analysis of monocyte subsets. J Cardiovasc Transl Res. 4, 211-9 (2011)(PMID:21308491)
  4. Hamann I et al. Analyses of phenotypic and functional characteristics of CX3CR1-expressing natural killer cells. Immunology 133, 62-73 (2011)(PMID:21320123)
  5. Havenith SH et al. Analysis of stem-cell-like properties of human CD161++IL-18Rα+ memory CD8+ T cells. Int Immunol. 24, 625-36 (2012)(PMID:22836020)
  6. Hamann I et al. Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation. J Neuroimmunol. 254, 165-9 (2013)(PMID:22948090)
  7. Bellora F et al. TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells. Eur J Immunol. 44, 1814-22 (2014)(PMID:24510590)
Product category
Research area
Cell surface antigens
Cytokine & Growth Factors
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 01:30, Jun 29, 2017 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.