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HOME > Product search results > Code No. D029-3 Anti-Drebrin mAb

Code No. D029-3

Anti-Drebrin mAb

Availability (in Japan)

10 or more

(In Japan at 00:05,
Oct 20, 2018 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

  • Immunoprecipitation

  • Immunocytochemistry

Clonality Monoclonal Clone M2F6
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 μg/mL  
IP
5 μg/250 μL of cell extract from 2.5 x 106 cells  
IC
1 μg/mL  
IH
reported.  (PMID: 3768727
Other(Immuno-EM)
reported.  (PMID: 8929425 / 12761245
Immunogen (Antigen) Purified chick drebrin E
Reactivity [Gene ID]

Human[1627], Mouse[56320], Rat[81653], Rabbit*(15458922/15790763), Bovine*[505406](9210216/12761245), Chicken*[396496](3768727)

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names DBN1, drebrin 1, D0S117E, drebrin, drebrin E, drebrin-1, drebrin E2, developmentally-regulated brain protein
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Citations

Western Blotting

  1. Shirao T and Obata K, Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution. Brain Res. 394, 233-244 (1986)(PMID:3768727)
  2. Counts SE, et al., Hippocampal drebrin loss in mild cognitive impairment. Neurodegener Dis.10, 216-219 (2012)(PMID:22310934)
  3. Hayashi K, et al., Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci. 16, 7161-7170 (1996)(PMID:8929425)
  4. Luna EJ, et al., Actin-binding membrane proteins identified by F-actin blot overlays. Soc Gen Physiol Ser. 52, 3-18 (1997)(PMID:9210216)
  5. Hayashi K and Shirao T. Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. J. Neurosci. 19, 3918-3925 (1999)(PMID:10234022)
  6. Keon BH, et al., Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia. J Cell Sci. 113, 325-336 (2000)(PMID:10633083)
  7. Fucini RV, et al., Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1. Mol Biol Cell. 13, 621-631 (2002)(PMID:11854417)
  8. Shim KS and Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci Lett. 324, 209-212 (2002)(PMID:12009525)
  9. Peitsch WK, et al., Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. J Am Soc Nephrol. 14, 1452-1463 (2003)(PMID:12761245)
  10. Takahashi H, et al., Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J. Neurosci. 23, 6586-6595 (2003)(PMID:12878700)
  11. Chew CS, et al., IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells. Am. J. Physiol. Gastrointest Liver Physiol. 288, G376-G387 (2005)(PMID:15458922)
  12. Chew CS, et al., Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 289, G320-31 (2005)(PMID:15790763)
  13. Zhao L, et al., Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 9, 234-242 (2006)(PMID:16415866)
  14. Xu W and Stamnes M. The actin-depolymerizing factor homology and charged/helical domains of drebrin and mAbp1 direct membrane binding and localization via distinct interactions with actin. J Biol Chem. 281, 11826-11833 (2006)(PMID:16452483)
  15. Lacor PN, et al., Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci. 27, 796-807 (2007)(PMID:17251419)
  16. Kramer ML and Schulz-Schaeffer WJ. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci. 27, 1405-1410. (2007)(PMID:17287515)
  17. Shiraishi-Yamaguchi Y, et al., Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines. BMC Neurosci. 10, 25 (2009)(PMID:19309525)
  18. Takahashi H, et al., Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. J Cell Sci. 122, 1211-1219 (2009)(PMID:19339553)

Immunoprecipitation

  1. Hayashi K, et al., Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci. 16, 7161-7170 (1996)(PMID:8929425)
  2. Chew CS, et al., Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 289, G320-31 (2005)(PMID:15790763)

Immunocytochemistry

  1. Hayashi K and Shirao T. Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. J. Neurosci. 19, 3918-3925 (1999)(PMID:10234022)
  2. Keon BH, et al., Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia. J Cell Sci. 113, 325-336 (2000)(PMID:10633083)
  3. Allison DW, et al., Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J Neurosci. 20, 4545-4554 (2000)(PMID:10844024)
  4. Chew CS, et al., Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 289, G320-31 (2005)(PMID:15790763)
  5. Zhao L, et al., Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 9, 234-242 (2006)(PMID:16415866)
  6. Takahashi H, et al., Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. J Cell Sci. 122, 1211-1219 (2009)(PMID:19339553)

Immunohistochemistry

  1. Shirao T and Obata K, Immunochemical homology of 3 developmentally regulated brain proteins and their developmental change in neuronal distribution. Brain Res. 394, 233-244 (1986)(PMID:3768727)
  2. Hayashi K, et al., Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci. 16, 7161-7170 (1996)(PMID:8929425)
  3. Keon BH, et al., Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia. J Cell Sci. 113, 325-336 (2000)(PMID:10633083)
  4. Peitsch WK, et al., Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. J Am Soc Nephrol. 14, 1452-1463 (2003)(PMID:12761245)
  5. Shapiro LA and Whitaker-Azmitia PM. Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43. Brain Res. 1019, 39-46 (2004)(PMID:15306236)

Other(Immuno-EM)

  1. Hayashi K, et al., Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. J Neurosci. 16, 7161-7170 (1996)(PMID:8929425)
  2. Peitsch WK, et al., Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. J Am Soc Nephrol. 14, 1452-1463 (2003)(PMID:12761245)
Product category
Research area
Stem cell research
Neuroscience
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  • The availability is based on the information in Japan at 00:05, Oct 20, 2018 in JST.
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  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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