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Regulation of translation


Code No. Product name Synonyms Reactivity Applications Function, localization
RN032P Anti-CIRBP pAb CIRP Hu/ Mo/ Rat WB/ IP/ RIP CIRBP is involved in cold stress-induced suppression of cell proliferation. It also serves as a translational activator under mild hypothermic conditions.
RN063PW Anti-DHX9 pAb NDHII, RHA Hu/ Mo/ Ham WB/ IP DHX9 is an RNA helicase that shuttles between nucleus and cytoplasm. DHX9 is recruited by LARP6 and involved in translational regulation by binding to the stem-loop structure in 5'-UTR of type I collagen mRNA.
RN003M Anti-EIF2C2 (AGO2) (Human) mAb AGO2 Hu WB/ IP/ RIP AGO2, a core component of RNA-induced silencing complex (RISC), plays a central role in RNAi pathway. It is reported that AGO2 is localized to P-body and involved in mRNA decay.
RN001P Anti-EIF4E pAb   Hu/ Mo/ Rat/ Ham WB/ IP/ RIP EIF4E, one of the translation-intiation factors, binds to m7G cap structure. Binding to inhibitory protein 4EBP inhibits its binding to eIF4G1 and cap-dependent translation.
RN006M Anti-EIF4E mAb   Hu/ Mo/ Rat/ Ham WB/ IP/ RIP EIF4E, one of the translation-intiation factors, binds to m7G cap structure. Binding to inhibitory protein 4EBP inhibits its binding to eIF4G1 and cap-dependent translation.
RN002P Anti-EIF4G1 (Human) pAb   Hu WB/ IP/ RIP/ IC/ IF EIF4G1 functions as a scaffold protein necessary for cap-dependent translation initiation.
RN003P Anti-EIF4G2 pAb   Hu/ Mo/ Rat/ Ham WB/ IP/ RIP EIF4G2, homologous to the C-terminal region of eIF4G1, functions as a translational inhibitor via forming an inactive complex with eIF4A and eIF3.
RN004P Anti-ELAVL1 (HuR) pAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ IC/ IF ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN007M Anti-ELAVL1 (HuR) mAb HuR Hu/ Mo/ Rat/ Ham WB/ IP/ RIP ELAVL1/HuR, a ubiquitously expressed protein, binds to both poly(A) and AU-rich element of mRNA. It is reported that HuR regulates mRNA export via shuttling between nucleus and cytoplasm.
RN005P Anti-ELAVL2 (HuB) (Human) pAb HuB Hu WB/ IP/ RIP/ IC/ IF ELAVL2/HuB, one of Hu family proteins, is specifically expressed in neuronal cells. It shuttles between nucleus and cytoplasm and regulates stabilization and translational efficiency of mRNAs via binding to AU-rich elements of them.
RN006P Anti-ELAVL3 (HuC) pAb HuC Hu/ Mo/ Rat WB/ IP/ RIP ELAVL3/HuC, a member of Hu protein family, may be related to neuronal development. It shuttles between nucleus and cytoplasm and regulates stability and translational efficiency of mRNAs via binding to AU-rich elements of them.
RN016P Anti-FMR1 pAb FMRP Hu/ Mo/ Rat WB/ IP/ RIP FMR1, one of the components of mRNP bound to polysome, serves as a translational repressor. FMR1 is a competitor of hnRNP C and negatively regulates translation of APP mRNA via recruiting it to P-body.
RN048PW Anti-G3BP1 pAb G3BP Hu WB/ IP G3BP1, a DNA/RNA helicase, is involved in stress granule formation. It also serves as a translational repressor via binding to mRNA of β-F1 ATPase.
RN114PW Anti-HNRNPA1 pAb   Hu/ Mo/ Rat/ Ham(w) WB/ IP HNRNPA1 is a multi-functional DNA/RNA binding protein involved in transcription, pre-mRNA splicing, stability, translation and miRNA biogenesis. HNRNPA1 participates in cap-independent translation by binding to IRES in mRNAs and viral RNA.
RN052PW Anti-HNRNPC pAb hnRNP C1/C2 Hu/ Mo WB/ IP HNRNPC positively regulates translation via binding to IRES of c-Myc, c-Sis and upstream of N-Ras. HNRNPC also promotes translation of APP mRNA via binding to the coding region of it in competition with FMR1.
RN060PW Anti-HNRNPD (AUF1) pAb AUF1 Hu/ Mo/ Rat/ Ham WB/ IP HNRNPD is related to mRNA decay through interaction with EIF4G1 and PABP in a translation-dependent manner.
RN019P Anti-HNRNPK pAb HNRPK Hu/ Mo/ Rat WB/ IP/ RIP/ IC* HNRNPK, one of the components of hnRNP complex, shuttles between nucleus and cytoplasm. It is related to splicing, transport and translational regulation of mRNA.
RN001M Anti-IGF2BP1 (IMP1) mAb IMP1, ZBP1 Hu/ Mo WB/ IP/ RIP IGF2BP1 represses translation initiation of β-actin mRNA via binding to it in nucleus and translocates to cytoplasm. When localized to destination in cytoplasm, IGF2BP1 bound to the mRNA is released from it by phosphorylation to intiate translation.
RN007P Anti-IGF2BP1 (IMP1) pAb IMP1, ZBP1 Hu/ Mo WB/ IP/ RIP/ IC/ IF IGF2BP1 represses translation initiation of β-actin mRNA via binding to it in nucleus and translocates to cytoplasm. When localized to destination in cytoplasm, IGF2BP1 bound to the mRNA is released from it by phosphorylation to intiate translation.
RN008P Anti-IGF2BP2 (IMP2) pAb IMP2 Hu/ Mo/ Rat WB/ IP/ RIP/ IC/ IF IGF2BP2 binds to the UTR of IGF2 leader 3 mRNA, which is related to development and proliferation, and regulates its translation.
RN009P Anti-IGF2BP3 (IMP3) pAb IMP3 Hu/ Mo WB/ IP/ RIP IGF2BP3 binds to the 5'-UTR of IGF2 leader 3 mRNA, which is related to development and proliferation, and regulates its translation.
RN066PW Anti-KIAA0020 pAb hPuf-A, HLA-HA8 Hu/ Mo/ Rat WB/ IP KIAA0020/hPuf-A contains one PUM-H domain and six Pumilio repeats, so it may be involved in translational regulation of mRNA. It is also reported to localize to the nucleolus.
RN127PW Anti-NSUN2 (Human) pAb MISU, MRT5, SAKI, TRM4 Hu WB/ IP NSUN2, identified as tRNA m5C methyltransferase, catalyzes the conversion of cytidine to m5C in tRNAs, mRNA and miRNA. m5C RNA modifications by NSUN2 affects mRNA stability, translation regulation and miRNA biogenesis.
RN009M Anti-PABPC1 mAb PABP1 Hu/ Ham WB/ IP/ RIP/ IC PABPC1 is involved in efficient translation of mRNA by forming a closed-loop structure through eIF4F complex, composed of eIF4E, eIF4A and eIF4G.
RN053PW Anti-PAIP1 pAb   Hu/ Rat WB/ IP PAIP1, a positive regulator of trasnlation, is involved in stabilization of interaction of PABP with EIF4G and formation of closed-loop structure of mRNA via binding to eIF3.
RN024P Anti-PCBP1 pAb HNRPE1 Hu/ Mo/ Rat WB/ IP/ RIP PCBP1 is one of the major PCBP isoforms shuttling between nucleus and cytoplasm. It serves as a translational coactivator via binding to stem-loop structure of IRES in poliovirus RNA.
RN025P Anti-PCBP2 pAb HNRPE2 Hu/ Mo/ Rat WB/ IP/ RIP PCBP2 binds to poly(rC) in the same way as PCBP1 and hnRNPK, and has been reported to the binding to poly(rU) as well. It also serves as a translational coactivator via binding to stem-loop structure of IRES in poliovirus RNA.
RN011P Anti-PTBP1 (Human) pAb hnRNPI Hu WB/ IP/ RIP/ IF* PTBP1 is related to IRES-dependent translation via binding to mRNA of IGFR1, VEGF and APAF1. It inhibits trasnlational repression via bindng to IRES in the mRNAs under the celluar stresses coditions such as viral infection and apoptosis.
RN004M Anti-Ribosomal P0/P1/P2 mAb RPLP0, RPLP1, RPLP2 Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ Inhibition test(Info. from the licenser) Ribosomal proteins P0 (34 kD), P1 (12 kD), P2 (12 kD) exist as a pentameric complex, P0(P1-P2)2 on the large subunits of eukaryotic ribosomes. This complex plays a crucial role in recruitment of translation factors to the ribosome.
RN080PW Anti-SRSF3 (SRp20) pAb SRp20 Hu/ Mo/ Rat/ Ham WB/ IP/ IC/ IF SRSF3/SRp20 is involved in IRES-dependent translation of polioviral RNAs through interaction with PCBP2.
RN082PW Anti-SRSF5 (SRP40) pAb SRP40 Hu/ Mo/ Rat/ Ham WB/ IP SRSF5/SRp40 is involved in splicing, transport, stabilization and translation of HIV-1 RNA. It is reported that SRSF5/SRp40 promotes translation of HIV-1 Gag from unspliced viral RNA.
RN079PW Anti-SRSF7 (9G8) pAb 9G8 Hu/ Mo/ Ham WB/ IP SRSF7/9G8 promotes translation of unspliced RNA cotaining a constitutive transport element of Mason Pfizer Monkey virus (MPMV).
RN014P Anti-TIA1 pAb   Hu/ Mo/ Rat/ Ham WB/ IP/ RIP TIA1 shuttles between nucleus and cytoplasm. It is involved in induction of apoptosis and translational regulation of TNF-α and COX-2 mRNAs.
RN059PW Anti-TIAL1 pAb TIAR Hu/ Rat/ Ham WB/ IP TIAL1 negatively regulates translation via binding to 3'-UTR of MYC mRNA in competition with AUF1.
RN033P Anti-TNRC6A (GW182) pAb GW182, GW1 Hu/ Mo/ Rat WB/ IP/ RIP/ IC* TNRC6A/GW182, associated with gene silencing by small ncRNA such as miRNA, has RNA recognition motif and several AGO binding domains. It serves as a trasnlational repressor of mRNA via binding to RISC components. It is reported that TNRC6A/GW182 is a major component of P-body/GW-body.
RN015P Anti-YBX1 pAb   Hu/ Mo/ Rat/ Ham WB/ IP/ RIP/ ChIP* YBX1, a member of cold shock protein family, is one of the main components of cytoplasmic mRNP particles. It is related to regulation of gene expression at transcriptional/translational level via binding to both DNA and RNA.

For applications:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.





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